XRCC2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of XRCC2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of XRCC2 at tissue level.

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0000278Biological processmitotic cell cycle
GO_0010165Biological processresponse to X-ray
GO_0001701Biological processin utero embryonic development
GO_0010332Biological processresponse to gamma radiation
GO_0050769Biological processpositive regulation of neurogenesis
GO_0035264Biological processmulticellular organism growth
GO_0007098Biological processcentrosome cycle
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0051321Biological processmeiotic cell cycle
GO_0022008Biological processneurogenesis
GO_0001756Biological processsomitogenesis
GO_2000269Biological processregulation of fibroblast apoptotic process
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0042148Biological processDNA strand invasion
GO_0005813Cellular componentcentrosome
GO_0005657Cellular componentreplication fork
GO_0005654Cellular componentnucleoplasm
GO_0033063Cellular componentRad51B-Rad51C-Rad51D-XRCC2 complex
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0140664Molecular functionATP-dependent DNA damage sensor activity
GO_0000400Molecular functionfour-way junction DNA binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameXRCC2
Protein nameX-ray repair cross complementing 2
DNA repair protein XRCC2 (X-ray repair cross-complementing protein 2)
Synonyms
DescriptionFUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. .

AccessionsO43543
ENST00000359321.2
A0A8V8TMB7
ENST00000698506.1