XPO7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006611Biological processprotein export from nucleus
GO_0005643Cellular componentnuclear pore
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005049Molecular functionnuclear export signal receptor activity
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding

IV. Literature review

[source]
Gene nameXPO7
Protein nameExportin 7
Exportin-7 (Exp7) (Ran-binding protein 16)
SynonymsKIAA0745
RANBP16
DescriptionFUNCTION: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. .

AccessionsE7ESC6
H0YBE1
ENST00000521303.5
ENST00000433566.8
ENST00000517551.2
E5RIW1
Q9UIA9
ENST00000252512.14