XPO5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006405Biological processRNA export from nucleus
GO_0035281Biological processpre-miRNA export from nucleus
GO_0006611Biological processprotein export from nucleus
GO_0010586Biological processmiRNA metabolic process
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016442Cellular componentRISC complex
GO_0042565Cellular componentRNA nuclear export complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_1905172Molecular functionRISC complex binding
GO_0000049Molecular functiontRNA binding
GO_0005049Molecular functionnuclear export signal receptor activity
GO_0070883Molecular functionpre-miRNA binding
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_0031267Molecular functionsmall GTPase binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameXPO5
Protein nameExportin-5 (Exp5) (Ran-binding protein 21)
Exportin 5
SynonymsRANBP21
KIAA1291
DescriptionFUNCTION: Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner.; FUNCTION: Mediates the nuclear export of micro-RNA precursors, which form short hairpins . Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs . Binding is dependent on Ran-GTP . .; FUNCTION: (Microbial infection) Mediates the nuclear export of adenovirus VA1 dsRNA. .

AccessionsENST00000265351.12
ENST00000496341.6
H0Y3W3
H0YA57
ENST00000455285.2
Q9HAV4
ENST00000486936.2
H0Y3Q8
ENST00000398835.7
ENST00000398799.2
E2QRM3
H0Y9I3