WHAMM report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007015Biological processactin filament organization
GO_0034314Biological processArp2/3 complex-mediated actin nucleation
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_0048041Biological processfocal adhesion assembly
GO_0051127Biological processpositive regulation of actin nucleation
GO_0097320Biological processplasma membrane tubulation
GO_0030032Biological processlamellipodium assembly
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0005874Cellular componentmicrotubule
GO_0005737Cellular componentcytoplasm
GO_0071933Molecular functionArp2/3 complex binding
GO_0003779Molecular functionactin binding
GO_0031267Molecular functionsmall GTPase binding
GO_0008017Molecular functionmicrotubule binding

IV. Literature review

[source]
Gene nameWHAMM
Protein nameWASP homolog-associated protein with actin, membranes and microtubules (WAS protein homology region 2 domain-containing protein 1) (WH2 domain-containing protein 1)
SynonymsKIAA1971
WHDC1
DescriptionFUNCTION: Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration. .

AccessionsENST00000286760.5
Q8TF30