Name | Number of supported studies | Average coverage | |
---|---|---|---|
natural killer cell | 10 studies | 22% ± 7% | |
B cell | 6 studies | 26% ± 9% | |
naive B cell | 6 studies | 22% ± 7% | |
CD16-negative, CD56-bright natural killer cell, human | 6 studies | 29% ± 11% | |
CD16-positive, CD56-dim natural killer cell, human | 5 studies | 28% ± 4% | |
CD4-positive, alpha-beta T cell | 4 studies | 31% ± 8% | |
CD8-positive, alpha-beta T cell | 4 studies | 25% ± 5% | |
endothelial cell | 4 studies | 22% ± 4% | |
epithelial cell | 4 studies | 33% ± 7% | |
innate lymphoid cell | 4 studies | 18% ± 2% | |
CD8-positive, alpha-beta memory T cell | 4 studies | 23% ± 1% | |
gamma-delta T cell | 4 studies | 21% ± 4% | |
CD4-positive, alpha-beta memory T cell | 4 studies | 18% ± 3% | |
T cell | 3 studies | 21% ± 3% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 3 studies | 28% ± 9% | |
effector memory CD4-positive, alpha-beta T cell | 3 studies | 24% ± 13% | |
GABAergic neuron | 3 studies | 23% ± 2% | |
glutamatergic neuron | 3 studies | 24% ± 5% | |
basal cell | 3 studies | 24% ± 4% | |
memory B cell | 3 studies | 18% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 2033.10 | 459 / 459 | 100% | 12.53 | 1118 / 1118 |
esophagus | 100% | 1641.50 | 1445 / 1445 | 100% | 12.04 | 183 / 183 |
intestine | 100% | 1745.13 | 966 / 966 | 100% | 10.83 | 527 / 527 |
pancreas | 100% | 1130.91 | 328 / 328 | 100% | 12.89 | 178 / 178 |
prostate | 100% | 2173.05 | 245 / 245 | 100% | 14.41 | 502 / 502 |
stomach | 100% | 1319.84 | 359 / 359 | 100% | 10.37 | 286 / 286 |
uterus | 100% | 1729.07 | 170 / 170 | 100% | 12.64 | 459 / 459 |
thymus | 100% | 1897.86 | 653 / 653 | 100% | 15.78 | 604 / 605 |
kidney | 100% | 1553.04 | 89 / 89 | 100% | 12.41 | 898 / 901 |
bladder | 100% | 1998.71 | 21 / 21 | 100% | 11.40 | 502 / 504 |
lung | 100% | 2094.25 | 578 / 578 | 100% | 10.90 | 1150 / 1155 |
ovary | 100% | 1813.28 | 180 / 180 | 99% | 7.51 | 427 / 430 |
brain | 99% | 1021.55 | 2618 / 2642 | 100% | 10.39 | 705 / 705 |
liver | 100% | 1205.99 | 226 / 226 | 99% | 7.25 | 402 / 406 |
skin | 100% | 1958.14 | 1809 / 1809 | 99% | 9.86 | 467 / 472 |
adrenal gland | 100% | 1194.99 | 258 / 258 | 97% | 7.90 | 224 / 230 |
adipose | 100% | 1938.59 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1682.05 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 11.78 | 29 / 29 |
muscle | 100% | 2656.23 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2214.80 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 12.50 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 6.46 | 1 / 1 |
heart | 99% | 928.35 | 849 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 94% | 6.57 | 75 / 80 |
peripheral blood | 94% | 1011.08 | 870 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007015 | Biological process | actin filament organization |
GO_0034314 | Biological process | Arp2/3 complex-mediated actin nucleation |
GO_0006888 | Biological process | endoplasmic reticulum to Golgi vesicle-mediated transport |
GO_0048041 | Biological process | focal adhesion assembly |
GO_0051127 | Biological process | positive regulation of actin nucleation |
GO_0097320 | Biological process | plasma membrane tubulation |
GO_0030032 | Biological process | lamellipodium assembly |
GO_0033116 | Cellular component | endoplasmic reticulum-Golgi intermediate compartment membrane |
GO_0000139 | Cellular component | Golgi membrane |
GO_0005829 | Cellular component | cytosol |
GO_0030659 | Cellular component | cytoplasmic vesicle membrane |
GO_0005874 | Cellular component | microtubule |
GO_0005737 | Cellular component | cytoplasm |
GO_0071933 | Molecular function | Arp2/3 complex binding |
GO_0003779 | Molecular function | actin binding |
GO_0031267 | Molecular function | small GTPase binding |
GO_0008017 | Molecular function | microtubule binding |
Gene name | WHAMM |
Protein name | WASP homolog-associated protein with actin, membranes and microtubules (WAS protein homology region 2 domain-containing protein 1) (WH2 domain-containing protein 1) |
Synonyms | KIAA1971 WHDC1 |
Description | FUNCTION: Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration. . |
Accessions | ENST00000286760.5 Q8TF30 |