WDR54 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0002091Biological processnegative regulation of receptor internalization
GO_0043408Biological processregulation of MAPK cascade
GO_0042058Biological processregulation of epidermal growth factor receptor signaling pathway
GO_0005930Cellular componentaxoneme
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0031982Cellular componentvesicle
GO_0042803Molecular functionprotein homodimerization activity

IV. Literature review

[source]
Gene nameWDR54
Protein nameWD repeat-containing protein 54
Synonyms
DescriptionFUNCTION: When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation. .

AccessionsENST00000348227.4 [Q9H977-1]
ENST00000409791.5 [Q9H977-3]
Q9H977