WASHC2C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000813Biological processnegative regulation of barbed-end actin filament capping
GO_0032456Biological processendocytic recycling
GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0016197Biological processendosomal transport
GO_1900024Biological processregulation of substrate adhesion-dependent cell spreading
GO_0015031Biological processprotein transport
GO_0034315Biological processregulation of Arp2/3 complex-mediated actin nucleation
GO_0036010Biological processprotein localization to endosome
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0005769Cellular componentearly endosome
GO_0031901Cellular componentearly endosome membrane
GO_0005829Cellular componentcytosol
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0071203Cellular componentWASH complex
GO_0005768Cellular componentendosome
GO_1905394Molecular functionretromer complex binding
GO_0005547Molecular functionphosphatidylinositol-3,4,5-trisphosphate binding
GO_0070273Molecular functionphosphatidylinositol-4-phosphate binding
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0032266Molecular functionphosphatidylinositol-3-phosphate binding
GO_0080025Molecular functionphosphatidylinositol-3,5-bisphosphate binding
GO_1901981Molecular functionphosphatidylinositol phosphate binding
GO_0005515Molecular functionprotein binding
GO_0010314Molecular functionphosphatidylinositol-5-phosphate binding
GO_0043325Molecular functionphosphatidylinositol-3,4-bisphosphate binding

IV. Literature review

[source]
Gene nameWASHC2C
Protein nameWASH complex subunit 2C (Vaccinia virus penetration factor) (VPEF)
WASH complex subunit 2C
SynonymsKIAA0592
FAM21C
VPEF
DescriptionFUNCTION: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission . Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 . Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35 . Required for the endosomal recruitment of CCC and retriever complexes subunits COMMD1 and CCDC93 as well as the retrievere complex subunit VPS35L . .; FUNCTION: (Microbial infection) Plays a role in fluid-phase endocytosis, a process exploited by vaccinia intracellular mature virus (IMV) to enter cells. As a result, may facilitate the penetration of IMV into cells. .

AccessionsJ3KP36
ENST00000537517.6 [Q9Y4E1-5]
ENST00000623400.4 [Q9Y4E1-7]
ENST00000540872.6 [Q9Y4E1-6]
Q9Y4E1
ENST00000420848.3
ENST00000374362.6 [Q9Y4E1-4]
ENST00000359860.7
A0A0A0MT65