WASHC2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0015031Biological processprotein transport
GO_0016197Biological processendosomal transport
GO_0034315Biological processregulation of Arp2/3 complex-mediated actin nucleation
GO_0036010Biological processprotein localization to endosome
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005730Cellular componentnucleolus
GO_0031901Cellular componentearly endosome membrane
GO_0071203Cellular componentWASH complex
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005769Cellular componentearly endosome
GO_1905394Molecular functionretromer complex binding
GO_1901981Molecular functionphosphatidylinositol phosphate binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameWASHC2A
Protein nameFAM21A protein
WASH complex subunit 2A
SynonymsFAM21A
FAM21B
DescriptionFUNCTION: Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. .

AccessionsQ641Q2
ENST00000399339.6
ENST00000351071.11 [Q641Q2-2]
A0A087WYF6
ENST00000314664.12
F8W7U3
ENST00000611324.4
Q5T1D7
E7ESD2
Q6P0Q7
ENST00000434114.6
B1AP61
ENST00000454806.1
B7ZME8
ENST00000282633.10 [Q641Q2-1]