WASH3P report

I. Expression across cell types

Insufficient scRNA-seq data for expression of WASH3P at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of WASH3P at tissue level.

III. Associated gene sets

GO_0006622Biological processprotein targeting to lysosome
GO_0032456Biological processendocytic recycling
GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0034314Biological processArp2/3 complex-mediated actin nucleation
GO_0016197Biological processendosomal transport
GO_0006887Biological processexocytosis
GO_0007032Biological processendosome organization
GO_0045022Biological processearly endosome to late endosome transport
GO_0034315Biological processregulation of Arp2/3 complex-mediated actin nucleation
GO_0055037Cellular componentrecycling endosome
GO_0005769Cellular componentearly endosome
GO_0031901Cellular componentearly endosome membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_0005814Cellular componentcentriole
GO_0030175Cellular componentfilopodium
GO_0005829Cellular componentcytosol
GO_0005776Cellular componentautophagosome
GO_0071203Cellular componentWASH complex
GO_0030027Cellular componentlamellipodium
GO_0043015Molecular functiongamma-tubulin binding
GO_0043014Molecular functionalpha-tubulin binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameWASH3P
Protein namePutative WAS protein family homolog 3 (Protein FAM39DP)
SynonymsFAM39DP
DescriptionFUNCTION: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting . Involved in endocytic trafficking of EGF . Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (By similarity). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (By similarity). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). .

AccessionsC4AMC7