VPS50 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0015031Biological processprotein transport
GO_0032456Biological processendocytic recycling
GO_0070062Cellular componentextracellular exosome
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0055037Cellular componentrecycling endosome
GO_1990745Cellular componentEARP complex
GO_0000149Molecular functionSNARE binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameVPS50
Protein nameVPS50 subunit of EARP/GARPII complex
Syndetin (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50)
CCDC132 protein
SynonymsCCDC132
KIAA1861
DescriptionFUNCTION: Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). .

AccessionsQ96JG6
F2Z3F0
A7MD03
ENST00000436177.5
F8WDT1
ENST00000544910.5 [Q96JG6-3]
C9JA29
ENST00000458530.1
ENST00000305866.10 [Q96JG6-1]
ENST00000443443.1
ENST00000441602.5
A0A3B3IRQ5
ENST00000649152.1
ENST00000458707.1
ENST00000251739.9 [Q96JG6-2]
H7BZP1
H0Y7Q2
ENST00000438395.5