VPS35L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015031Biological processprotein transport
GO_0032456Biological processendocytic recycling
GO_0006893Biological processGolgi to plasma membrane transport
GO_0005768Cellular componentendosome
GO_0005886Cellular componentplasma membrane
GO_0101003Cellular componentficolin-1-rich granule membrane
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameVPS35L
Protein nameVPS35 endosomal protein-sorting factor-like (Esophageal cancer-associated protein)
VPS35 endosomal protein-sorting factor-like
VPS35 endosomal protein sorting factor like
SynonymshCG_1993553
101F10.2
C16orf62
MGC16824
DescriptionFUNCTION: Acts as a component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) . The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes . In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling . Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association with the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability . .; FUNCTION: (Microbial infection) The heterotrimeric retriever complex, in collaboration with the CCC complex, mediates the exit of human papillomavirus to the cell surface. .

AccessionsENST00000543152.5
H3BNX2
ENST00000542263.5
ENST00000567245.5
H3BUS7
ENST00000251143.9
ENST00000539322.5
H3BTI5
ENST00000542027.3
F5H7K1
H3BVG8
F6S1J4
H3BV68
ENST00000417362.7 [Q7Z3J2-1]
ENST00000537186.6
ENST00000513947.8
I3L1U5
Q7Z3J2
ENST00000544670.5
H0YFG6
ENST00000563649.1
E7EWW0
H3BRV8
ENST00000538552.5