VPS33A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of VPS33A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of VPS33A at tissue level.

III. Associated gene sets

GO_0048070Biological processregulation of developmental pigmentation
GO_0032400Biological processmelanosome localization
GO_0006886Biological processintracellular protein transport
GO_0016192Biological processvesicle-mediated transport
GO_0035751Biological processregulation of lysosomal lumen pH
GO_0008333Biological processendosome to lysosome transport
GO_0032418Biological processlysosome localization
GO_0035542Biological processregulation of SNARE complex assembly
GO_0097352Biological processautophagosome maturation
GO_0030220Biological processplatelet formation
GO_0034058Biological processendosomal vesicle fusion
GO_0033263Cellular componentCORVET complex
GO_0031902Cellular componentlate endosome membrane
GO_0030897Cellular componentHOPS complex
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005769Cellular componentearly endosome
GO_0005764Cellular componentlysosome
GO_0030136Cellular componentclathrin-coated vesicle
GO_0071439Cellular componentclathrin complex
GO_0030123Cellular componentAP-3 adaptor complex
GO_0005770Cellular componentlate endosome
GO_0005776Cellular componentautophagosome
GO_0010008Cellular componentendosome membrane
GO_0005765Cellular componentlysosomal membrane
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameVPS33A
Protein nameVacuolar protein sorting-associated protein 33A
Alternative protein VPS33A
VPS33A core subunit of CORVET and HOPS complexes
Vacuolar protein sorting-associated protein 33A (hVPS33A)
Synonyms
DescriptionFUNCTION: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations . Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39 . The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG . .

AccessionsENST00000543633.5
A0A2R8Y5U3
ENST00000643696.1
F5H2X5
ENST00000451053.3
A0A2R8YF87
ENST00000267199.9
F5H7N5
ENST00000544349.6
ENST00000541169.1
L8EAC9
Q96AX1
F5H6Y0
ENST00000536212.2
A0A2R8Y5F6