VPS25 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043328Biological processprotein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO_0016236Biological processmacroautophagy
GO_0007175Biological processnegative regulation of epidermal growth factor-activated receptor activity
GO_0036258Biological processmultivesicular body assembly
GO_0090148Biological processmembrane fission
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0010008Cellular componentendosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000814Cellular componentESCRT II complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0005198Molecular functionstructural molecule activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameVPS25
Protein nameVacuolar protein-sorting-associated protein 25 (ESCRT-II complex subunit VPS25)
Vacuolar protein-sorting-associated protein 25 (hVps25) (Dermal papilla-derived protein 9) (ELL-associated protein of 20 kDa) (ESCRT-II complex subunit VPS25)
SynonymsDERP9
EAP20
DescriptionFUNCTION: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses. .

AccessionsK7EP45
Q9BRG1
ENST00000589577.1
ENST00000253794.7
ENST00000589520.1
K7ENE3
K7EKV4
ENST00000590339.5