Name | Number of supported studies | Average coverage | |
---|---|---|---|
ciliated cell | 9 studies | 34% ± 14% | |
epithelial cell | 8 studies | 35% ± 20% | |
fibroblast | 6 studies | 25% ± 7% | |
natural killer cell | 6 studies | 18% ± 3% | |
endothelial cell | 5 studies | 27% ± 11% | |
pericyte | 5 studies | 19% ± 5% | |
regulatory T cell | 5 studies | 17% ± 2% | |
classical monocyte | 4 studies | 25% ± 8% | |
kidney loop of Henle epithelial cell | 4 studies | 19% ± 5% | |
connective tissue cell | 4 studies | 23% ± 4% | |
myofibroblast cell | 4 studies | 17% ± 1% | |
basal cell | 4 studies | 33% ± 17% | |
CD8-positive, alpha-beta T cell | 4 studies | 17% ± 1% | |
goblet cell | 4 studies | 25% ± 11% | |
plasmacytoid dendritic cell | 4 studies | 26% ± 7% | |
plasmablast | 3 studies | 47% ± 15% | |
pancreatic A cell | 3 studies | 31% ± 10% | |
hematopoietic precursor cell | 3 studies | 25% ± 4% | |
non-classical monocyte | 3 studies | 28% ± 5% | |
smooth muscle cell | 3 studies | 17% ± 2% | |
type I pneumocyte | 3 studies | 23% ± 4% | |
erythroblast | 3 studies | 30% ± 14% | |
abnormal cell | 3 studies | 22% ± 5% | |
macrophage | 3 studies | 22% ± 3% | |
dendritic cell | 3 studies | 32% ± 7% | |
enteroendocrine cell | 3 studies | 30% ± 18% | |
CD4-positive, alpha-beta T cell | 3 studies | 19% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2322.06 | 1445 / 1445 | 100% | 69.91 | 183 / 183 |
liver | 100% | 1681.27 | 226 / 226 | 100% | 65.06 | 406 / 406 |
ovary | 100% | 1472.69 | 180 / 180 | 100% | 70.21 | 430 / 430 |
pancreas | 100% | 1270.72 | 328 / 328 | 100% | 66.95 | 178 / 178 |
stomach | 100% | 1784.94 | 359 / 359 | 100% | 86.22 | 286 / 286 |
intestine | 100% | 1859.10 | 966 / 966 | 100% | 90.17 | 526 / 527 |
prostate | 100% | 1968.19 | 245 / 245 | 100% | 74.04 | 501 / 502 |
skin | 100% | 2476.84 | 1809 / 1809 | 100% | 89.04 | 471 / 472 |
uterus | 100% | 1593.76 | 170 / 170 | 100% | 88.38 | 458 / 459 |
kidney | 100% | 2633.84 | 89 / 89 | 100% | 78.10 | 899 / 901 |
breast | 100% | 1973.36 | 459 / 459 | 100% | 88.13 | 1113 / 1118 |
thymus | 100% | 1795.32 | 653 / 653 | 100% | 60.56 | 602 / 605 |
bladder | 100% | 1671.67 | 21 / 21 | 99% | 87.99 | 500 / 504 |
lung | 99% | 1570.63 | 573 / 578 | 100% | 77.54 | 1155 / 1155 |
brain | 99% | 919.19 | 2609 / 2642 | 100% | 60.38 | 705 / 705 |
adrenal gland | 100% | 1817.74 | 258 / 258 | 95% | 37.58 | 218 / 230 |
adipose | 100% | 1707.60 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 79.57 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 74.64 | 29 / 29 |
spleen | 100% | 1712.16 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 81.83 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 48.81 | 1 / 1 |
muscle | 100% | 1370.55 | 800 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1384.04 | 1330 / 1335 | 0% | 0 | 0 / 0 |
heart | 98% | 1154.75 | 847 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 96% | 1905.81 | 888 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0043328 | Biological process | protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
GO_0016236 | Biological process | macroautophagy |
GO_0007175 | Biological process | negative regulation of epidermal growth factor-activated receptor activity |
GO_0036258 | Biological process | multivesicular body assembly |
GO_0090148 | Biological process | membrane fission |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0010008 | Cellular component | endosome membrane |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0000814 | Cellular component | ESCRT II complex |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0005198 | Molecular function | structural molecule activity |
GO_0005515 | Molecular function | protein binding |
Gene name | VPS25 |
Protein name | Vacuolar protein-sorting-associated protein 25 (ESCRT-II complex subunit VPS25) Vacuolar protein-sorting-associated protein 25 (hVps25) (Dermal papilla-derived protein 9) (ELL-associated protein of 20 kDa) (ESCRT-II complex subunit VPS25) |
Synonyms | DERP9 EAP20 |
Description | FUNCTION: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses. . |
Accessions | K7EP45 Q9BRG1 ENST00000589577.1 ENST00000253794.7 ENST00000589520.1 K7ENE3 K7EKV4 ENST00000590339.5 |