VPS16 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of VPS16 at tissue level.

III. Associated gene sets

GO_0006886Biological processintracellular protein transport
GO_0016197Biological processendosomal transport
GO_0008333Biological processendosome to lysosome transport
GO_0042144Biological processvacuole fusion, non-autophagic
GO_0035542Biological processregulation of SNARE complex assembly
GO_0097352Biological processautophagosome maturation
GO_0034058Biological processendosomal vesicle fusion
GO_0033263Cellular componentCORVET complex
GO_0031902Cellular componentlate endosome membrane
GO_0030897Cellular componentHOPS complex
GO_0055037Cellular componentrecycling endosome
GO_0005769Cellular componentearly endosome
GO_0005764Cellular componentlysosome
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005770Cellular componentlate endosome
GO_0005776Cellular componentautophagosome
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0005765Cellular componentlysosomal membrane
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameVPS16
Protein nameVPS16 core subunit of CORVET and HOPS complexes
VPS16 protein
Vacuolar protein sorting-associated protein 16 homolog (hVPS16)
Vacuolar protein sorting-associated protein 16 homolog
Synonyms
DescriptionFUNCTION: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations . Required for recruitment of VPS33A to the HOPS complex . Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS33A but not VPS33B . The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG . .

AccessionsENST00000417508.1
Q5JUB0
Q9H269
Q6GMQ7
A1A4H0
ENST00000453689.5
Q5JUA9
ENST00000380469.7 [Q9H269-2]
ENST00000380445.8 [Q9H269-1]