UTP3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of UTP3 at tissue level.

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0007420Biological processbrain development
GO_0000462Biological processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO_0042274Biological processribosomal small subunit biogenesis
GO_0005730Cellular componentnucleolus
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0032040Cellular componentsmall-subunit processome
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameUTP3
Protein nameSomething about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (CRL1) (Disrupter of silencing SAS10) (UTP3 homolog)
SynonymsCRLZ1
SAS10
DescriptionFUNCTION: Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome . .

AccessionsQ9NQZ2
ENST00000254803.4