USP6 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of USP6 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	97%	1241.49	174 / 180	9%	0.20	40 / 430
thymus	85%	499.07	558 / 653	15%	0.38	90 / 605
muscle	100%	4897.51	801 / 803	0%	0	0 / 0
prostate	80%	392.71	195 / 245	3%	0.05	17 / 502
breast	69%	505.34	318 / 459	5%	0.10	56 / 1118
brain	63%	143.02	1652 / 2642	11%	0.44	80 / 705
spleen	66%	191.78	159 / 241	0%	0	0 / 0
kidney	51%	246.64	45 / 89	7%	0.20	59 / 901
uterus	46%	368.28	79 / 170	8%	0.26	37 / 459
lung	46%	216.49	265 / 578	3%	0.06	32 / 1155
adipose	44%	261.94	530 / 1204	0%	0	0 / 0
skin	31%	146.94	554 / 1809	6%	0.16	28 / 472
intestine	34%	308.84	331 / 966	1%	0.01	4 / 527
bladder	29%	232.14	6 / 21	2%	0.05	9 / 504
esophagus	24%	242.84	342 / 1445	3%	0.04	6 / 183
stomach	18%	113.86	64 / 359	2%	0.03	6 / 286
pancreas	16%	78.51	52 / 328	3%	0.04	5 / 178
blood vessel	18%	104.04	238 / 1335	0%	0	0 / 0
adrenal gland	16%	37.33	41 / 258	1%	0.02	2 / 230
heart	16%	120.27	136 / 861	0%	0	0 / 0
liver	9%	17.84	20 / 226	0%	0.01	2 / 406
tonsil	0%	0	0 / 0	7%	0.20	3 / 45
peripheral blood	4%	30.54	40 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	4%	0.05	3 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0060627	Biological process	regulation of vesicle-mediated transport
GO_0016579	Biological process	protein deubiquitination
GO_0036211	Biological process	protein modification process
GO_0006508	Biological process	proteolysis
GO_0099149	Biological process	regulation of postsynaptic neurotransmitter receptor internalization
GO_0098978	Cellular component	glutamatergic synapse
GO_0005764	Cellular component	lysosome
GO_0055037	Cellular component	recycling endosome
GO_0099092	Cellular component	postsynaptic density, intracellular component
GO_0005794	Cellular component	Golgi apparatus
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0005516	Molecular function	calmodulin binding
GO_0004197	Molecular function	cysteine-type endopeptidase activity
GO_0005515	Molecular function	protein binding
GO_0003676	Molecular function	nucleic acid binding
GO_0004843	Molecular function	cysteine-type deubiquitinase activity

Gene name	USP6
Protein name	Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.4.19.12) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2) (RN-tre) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6) Oncogene (Ubiquitin specific peptidase 6) Alternative protein USP6
Synonyms	tre HRP1 TRE2
Description	FUNCTION: Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. May act as a GTPase-activating protein for RAB3A . .
Accessions	ENST00000574788.6 [P35125-1] P35125 Q15635 L8E827 ENST00000575709.5 ENST00000572949.5 [P35125-3] ENST00000250066.6 [P35125-1]

USP6 report