USP50 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of USP50 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	98%	15.61	87 / 89	6%	0.10	54 / 901
thymus	97%	11.04	634 / 653	6%	0.07	34 / 605
bladder	90%	4.86	19 / 21	5%	0.10	23 / 504
breast	92%	8.27	423 / 459	3%	0.07	30 / 1118
liver	93%	11.31	211 / 226	1%	0.01	3 / 406
adipose	93%	8.93	1116 / 1204	0%	0	0 / 0
prostate	88%	6.13	216 / 245	1%	0.02	6 / 502
spleen	89%	5.56	215 / 241	0%	0	0 / 0
lung	81%	4.79	471 / 578	7%	0.14	80 / 1155
esophagus	61%	2.74	888 / 1445	26%	0.35	47 / 183
skin	84%	6.86	1525 / 1809	3%	0.04	13 / 472
ovary	77%	3.92	138 / 180	3%	0.03	11 / 430
adrenal gland	74%	3.69	190 / 258	1%	0.01	2 / 230
uterus	73%	3.59	124 / 170	1%	0.03	5 / 459
intestine	68%	3.26	658 / 966	4%	0.06	21 / 527
blood vessel	69%	3.49	915 / 1335	0%	0	0 / 0
heart	67%	3.06	573 / 861	0%	0	0 / 0
stomach	54%	2.11	195 / 359	6%	0.13	18 / 286
brain	60%	3.07	1573 / 2642	1%	0.01	4 / 705
pancreas	53%	2.02	174 / 328	3%	0.06	6 / 178
muscle	43%	1.65	343 / 803	0%	0	0 / 0
peripheral blood	31%	0.95	288 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_1902749	Biological process	regulation of cell cycle G2/M phase transition
GO_0071108	Biological process	protein K48-linked deubiquitination
GO_0007265	Biological process	Ras protein signal transduction
GO_0035063	Biological process	nuclear speck organization
GO_0032731	Biological process	positive regulation of interleukin-1 beta production
GO_1900227	Biological process	positive regulation of NLRP3 inflammasome complex assembly
GO_0032741	Biological process	positive regulation of interleukin-18 production
GO_0070536	Biological process	protein K63-linked deubiquitination
GO_2001056	Biological process	positive regulation of cysteine-type endopeptidase activity
GO_0007032	Biological process	endosome organization
GO_0016579	Biological process	protein deubiquitination
GO_0030496	Cellular component	midbody
GO_0043197	Cellular component	dendritic spine
GO_0005813	Cellular component	centrosome
GO_0005829	Cellular component	cytosol
GO_0014069	Cellular component	postsynaptic density
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0004843	Molecular function	cysteine-type deubiquitinase activity
GO_0019783	Molecular function	ubiquitin-like protein peptidase activity

Gene name	USP50
Protein name	Ubiquitin specific peptidase 50 Alternative protein USP50 Ubiquitin carboxyl-terminal hydrolase 50 (EC 3.4.19.12) (Ubiquitin-specific peptidase 50)
Synonyms
Description	FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates the inflammasome signaling pathway by deubiquitinating 'Lys-63'-linked polyubiquitination of the PYCARD/ASC adapter protein . Regulates the ubiquitination and stability of the ACE2 protein . Acts as a negative regulator of the G2/M checkpoint pathway, by preventing serine/threonine kinase WEE1 degradation, thereby repressing entry into mitosis following activation of the G2/M DNA damage checkpoint . .
Accessions	L8EBI2 H0YDN5 ENST00000616326.1 ENST00000559105.5 ENST00000529349.2 ENST00000673895.1 H0YNB9 Q70EL3 A0A669KB43 ENST00000532404.6 [Q70EL3-2] A0A087X0L6

USP50 report