USP49 | OmnibusX

Name	Number of supported studies	Average coverage
oligodendrocyte precursor cell	7 studies	26% ± 11%	Explore
GABAergic neuron	7 studies	39% ± 17%	Explore
interneuron	6 studies	36% ± 21%	Explore
glutamatergic neuron	5 studies	48% ± 20%	Explore
astrocyte	5 studies	28% ± 10%	Explore
endothelial cell	3 studies	27% ± 12%	Explore
GABAergic interneuron	3 studies	21% ± 7%	Explore
oligodendrocyte	3 studies	25% ± 6%	Explore

Name	Number of supported studies	Average coverage
brain	6 studies	37% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	779.41	1443 / 1445	99%	4.05	182 / 183
brain	100%	1202.56	2638 / 2642	99%	8.20	699 / 705
breast	100%	1091.37	459 / 459	95%	3.32	1064 / 1118
lung	100%	1118.37	577 / 578	94%	3.05	1083 / 1155
uterus	100%	1338.58	170 / 170	92%	3.17	422 / 459
prostate	100%	991.62	245 / 245	90%	2.15	452 / 502
thymus	100%	2674.35	653 / 653	90%	2.81	542 / 605
bladder	100%	992.10	21 / 21	87%	2.32	440 / 504
stomach	100%	610.23	358 / 359	87%	2.19	248 / 286
intestine	100%	865.28	966 / 966	86%	1.84	455 / 527
pancreas	99%	448.58	324 / 328	85%	1.83	152 / 178
ovary	100%	1205.64	180 / 180	83%	2.52	358 / 430
skin	100%	1157.97	1809 / 1809	83%	3.03	391 / 472
adrenal gland	100%	1107.80	258 / 258	82%	2.09	189 / 230
kidney	100%	644.08	89 / 89	73%	1.68	662 / 901
liver	94%	343.56	213 / 226	47%	0.88	190 / 406
adipose	100%	1042.33	1204 / 1204	0%	0	0 / 0
spleen	100%	753.85	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	1.64	1 / 1
blood vessel	100%	862.85	1332 / 1335	0%	0	0 / 0
muscle	100%	558.19	799 / 803	0%	0	0 / 0
heart	94%	524.79	813 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	3.03	27 / 29
peripheral blood	92%	783.23	858 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	84%	2.76	38 / 45
eye	0%	0	0 / 0	79%	2.72	63 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0006338	Biological process	chromatin remodeling
GO_0051898	Biological process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0006508	Biological process	proteolysis
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0140936	Molecular function	histone H2B deubiquitinase activity
GO_0004197	Molecular function	cysteine-type endopeptidase activity
GO_0005515	Molecular function	protein binding
GO_0004843	Molecular function	cysteine-type deubiquitinase activity
GO_0008270	Molecular function	zinc ion binding
GO_0042393	Molecular function	histone binding

Gene name	USP49
Protein name	Ubiquitin specific peptidase 49 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.4.19.12) (Deubiquitinating enzyme 49) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49)
Synonyms
Description	FUNCTION: Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons. .
Accessions	ENST00000394253.7 [Q70CQ1-1] ENST00000373006.5 [Q70CQ1-2] Q5T3E1 ENST00000423567.1 ENST00000448078.1 ENST00000682992.1 [Q70CQ1-1] H7BZI7 A6PVU3 ENST00000373010.5 Q70CQ1

USP49 report