USP28 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0042771Biological processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0016579Biological processprotein deubiquitination
GO_0071947Biological processprotein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO_0006281Biological processDNA repair
GO_0008283Biological processcell population proliferation
GO_0010212Biological processresponse to ionizing radiation
GO_0034644Biological processcellular response to UV
GO_0031647Biological processregulation of protein stability
GO_0000077Biological processDNA damage checkpoint signaling
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016604Cellular componentnuclear body
GO_0005634Cellular componentnucleus
GO_0101005Molecular functiondeubiquitinase activity
GO_0005515Molecular functionprotein binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity

IV. Literature review

[source]
Gene nameUSP28
Protein nameAlternative protein USP28
Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12)
Ubiquitin specific peptidase 28
Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28)
SynonymsKIAA1515
hCG_39594
DescriptionFUNCTION: Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells . .

FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. .

AccessionsENST00000537490.1
A0A8V8TLZ9
ENST00000540925.5
ENST00000003302.8 [Q96RU2-1]
ENST00000545608.5
ENST00000538475.5
ENST00000545540.5
H0YFX3
ENST00000544967.5
ENST00000696973.1
ENST00000696972.1
H0YFD7
B4E3L3
ENST00000537706.5 [Q96RU2-3]
ENST00000538224.1
F5H2G4
ENST00000544750.1
H0YFA0
ENST00000537642.1
H0YFT9
H0YG96
Q96RU2
ENST00000535607.5
H0YH19
L8EA89
G3V1N5
F5GZ74
F5H6Q3
ENST00000540438.5
A0A8V8TKW5