Name | Number of supported studies | Average coverage | |
---|---|---|---|
natural killer cell | 16 studies | 18% ± 3% | |
CD16-positive, CD56-dim natural killer cell, human | 8 studies | 20% ± 4% | |
glutamatergic neuron | 6 studies | 39% ± 23% | |
CD16-negative, CD56-bright natural killer cell, human | 5 studies | 22% ± 5% | |
cardiac muscle cell | 5 studies | 39% ± 7% | |
astrocyte | 5 studies | 22% ± 6% | |
endothelial cell | 4 studies | 25% ± 7% | |
CD8-positive, alpha-beta T cell | 4 studies | 17% ± 2% | |
epithelial cell | 4 studies | 24% ± 1% | |
GABAergic neuron | 4 studies | 35% ± 10% | |
oligodendrocyte precursor cell | 4 studies | 23% ± 5% | |
interneuron | 4 studies | 34% ± 19% | |
oligodendrocyte | 4 studies | 20% ± 3% | |
B cell | 3 studies | 17% ± 1% | |
lymphocyte | 3 studies | 17% ± 1% | |
transit amplifying cell | 3 studies | 26% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 1740.41 | 180 / 180 | 100% | 26.17 | 430 / 430 |
esophagus | 100% | 1702.07 | 1442 / 1445 | 100% | 21.80 | 183 / 183 |
prostate | 100% | 2114.89 | 245 / 245 | 100% | 14.95 | 500 / 502 |
uterus | 100% | 1877.10 | 170 / 170 | 100% | 17.97 | 457 / 459 |
bladder | 100% | 1887.62 | 21 / 21 | 99% | 14.87 | 501 / 504 |
stomach | 100% | 1223.76 | 358 / 359 | 100% | 16.57 | 285 / 286 |
thymus | 100% | 1405.27 | 653 / 653 | 99% | 14.87 | 601 / 605 |
lung | 99% | 1254.61 | 573 / 578 | 100% | 21.74 | 1155 / 1155 |
breast | 100% | 1318.63 | 457 / 459 | 100% | 17.65 | 1113 / 1118 |
intestine | 100% | 1832.26 | 966 / 966 | 99% | 14.67 | 520 / 527 |
kidney | 100% | 1081.97 | 89 / 89 | 98% | 11.99 | 880 / 901 |
pancreas | 97% | 786.31 | 319 / 328 | 99% | 10.56 | 177 / 178 |
brain | 94% | 1432.86 | 2474 / 2642 | 100% | 12.73 | 704 / 705 |
skin | 99% | 1290.50 | 1788 / 1809 | 93% | 10.68 | 439 / 472 |
liver | 98% | 782.58 | 222 / 226 | 90% | 7.32 | 367 / 406 |
adrenal gland | 97% | 1002.72 | 250 / 258 | 84% | 5.92 | 193 / 230 |
lymph node | 0% | 0 | 0 / 0 | 100% | 20.06 | 29 / 29 |
muscle | 100% | 5490.87 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1989.67 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 17.43 | 45 / 45 |
blood vessel | 100% | 1478.70 | 1333 / 1335 | 0% | 0 | 0 / 0 |
adipose | 98% | 1080.55 | 1179 / 1204 | 0% | 0 | 0 / 0 |
heart | 98% | 5532.50 | 840 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 83% | 7.39 | 66 / 80 |
peripheral blood | 71% | 1364.57 | 656 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006974 | Biological process | DNA damage response |
GO_0042771 | Biological process | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
GO_0016579 | Biological process | protein deubiquitination |
GO_0071947 | Biological process | protein deubiquitination involved in ubiquitin-dependent protein catabolic process |
GO_0006281 | Biological process | DNA repair |
GO_0008283 | Biological process | cell population proliferation |
GO_0010212 | Biological process | response to ionizing radiation |
GO_0034644 | Biological process | cellular response to UV |
GO_0031647 | Biological process | regulation of protein stability |
GO_0000077 | Biological process | DNA damage checkpoint signaling |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0016604 | Cellular component | nuclear body |
GO_0005634 | Cellular component | nucleus |
GO_0101005 | Molecular function | deubiquitinase activity |
GO_0005515 | Molecular function | protein binding |
GO_0004843 | Molecular function | cysteine-type deubiquitinase activity |
Gene name | USP28 |
Protein name | Alternative protein USP28 Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) Ubiquitin specific peptidase 28 Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) |
Synonyms | KIAA1515 hCG_39594 |
Description | FUNCTION: Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells . . FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. . |
Accessions | ENST00000537490.1 A0A8V8TLZ9 ENST00000540925.5 ENST00000003302.8 [Q96RU2-1] ENST00000545608.5 ENST00000538475.5 ENST00000545540.5 H0YFX3 ENST00000544967.5 ENST00000696973.1 ENST00000696972.1 H0YFD7 B4E3L3 ENST00000537706.5 [Q96RU2-3] ENST00000538224.1 F5H2G4 ENST00000544750.1 H0YFA0 ENST00000537642.1 H0YFT9 H0YG96 Q96RU2 ENST00000535607.5 H0YH19 L8EA89 G3V1N5 F5GZ74 F5H6Q3 ENST00000540438.5 A0A8V8TKW5 |