USP26 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of USP26 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of USP26 at tissue level.

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0006508Biological processproteolysis
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0016579Biological processprotein deubiquitination
GO_0060765Biological processregulation of androgen receptor signaling pathway
GO_0005856Cellular componentcytoskeleton
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0036126Cellular componentsperm flagellum
GO_0005634Cellular componentnucleus
GO_0101005Molecular functiondeubiquitinase activity
GO_0005515Molecular functionprotein binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_1990380Molecular functionK48-linked deubiquitinase activity

IV. Literature review

[source]
Gene nameUSP26
Protein nameUbiquitin carboxyl-terminal hydrolase (EC 3.4.19.12)
Ubiquitin carboxyl-terminal hydrolase 26 (EC 3.4.19.12) (Deubiquitinating enzyme 26) (Ubiquitin thioesterase 26) (Ubiquitin-specific-processing protease 26)
Synonyms
DescriptionFUNCTION: Deubiquitinase regulating several biological processes through the deubiquitination of components of these processes . Involved in somatic cell reprogramming through the 'Lys-48'-linked deubiquitination and stabilization of CBX4 and CBX6, two components of the polycomb-repressive complex 1 (PRC1) . Also deubiquitinates and probably stabilizes the androgen receptor (AR), regulating the androgen receptor signaling pathway . May play a role in spermatogenesis . .

FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. .

AccessionsQ495F8
Q9BXU7
ENST00000370832.1
ENST00000511190.6