USP21 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of USP21 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of USP21 at tissue level.

III. Associated gene sets

GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006508Biological processproteolysis
GO_0045815Biological processtranscription initiation-coupled chromatin remodeling
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0003713Molecular functiontranscription coactivator activity
GO_0019784Molecular functiondeNEDDylase activity
GO_0008234Molecular functioncysteine-type peptidase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity

IV. Literature review

[source]
Gene nameUSP21
Protein nameUbiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21)
Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12)
Alternative protein USP21
Ubiquitin specific peptidase 21
SynonymsUSP23
PP1490
DescriptionFUNCTION: Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (By similarity). Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation (By similarity). Regulates gene expression via histone H2A deubiquitination (By similarity). Deubiquitinates BAZ2A/TIP5 leading to its stabilization . Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates . Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination . .

FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. .

AccessionsENST00000486299.5
A0A1W2PRX0
V9GY36
A0A8Q3SIU3
L8E8G0
V9GYJ6
ENST00000696603.1
ENST00000289865.12 [Q9UK80-1]
ENST00000368001.1 [Q9UK80-3]
ENST00000368002.8 [Q9UK80-1]
ENST00000493054.5
ENST00000492950.5
A0A1W2PQ32
Q9UK80
ENST00000479344.1