USP20 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071108Biological processprotein K48-linked deubiquitination
GO_0006897Biological processendocytosis
GO_0070536Biological processprotein K63-linked deubiquitination
GO_0008277Biological processregulation of G protein-coupled receptor signaling pathway
GO_0010508Biological processpositive regulation of autophagy
GO_0006508Biological processproteolysis
GO_0016579Biological processprotein deubiquitination
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0140374Biological processantiviral innate immune response
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005813Cellular componentcentrosome
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0001664Molecular functionG protein-coupled receptor binding
GO_0008270Molecular functionzinc ion binding
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUSP20
Protein nameUbiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2)
SynonymsVDU2
LSFR3A
KIAA1003
DescriptionFUNCTION: Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis . Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination . Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization . Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 . Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability . Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 . This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity . Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability . Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol . .

AccessionsENST00000315480.9
Q9Y2K6
ENST00000358355.5
ENST00000372429.8