Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| type I pneumocyte | 10 studies | 30% ± 10% | |
| natural killer cell | 7 studies | 18% ± 3% | |
| CD16-positive, CD56-dim natural killer cell, human | 5 studies | 19% ± 3% | |
| non-classical monocyte | 5 studies | 26% ± 9% | |
| CD16-negative, CD56-bright natural killer cell, human | 4 studies | 19% ± 3% | |
| CD8-positive, alpha-beta T cell | 3 studies | 18% ± 2% | |
| classical monocyte | 3 studies | 29% ± 7% | |
| hematopoietic precursor cell | 3 studies | 21% ± 4% |
Insufficient scRNA-seq data for expression of UNC13D at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 7889.64 | 578 / 578 | 93% | 23.36 | 1078 / 1155 |
| bladder | 100% | 2022.38 | 21 / 21 | 92% | 33.61 | 465 / 504 |
| esophagus | 94% | 2193.31 | 1364 / 1445 | 93% | 26.65 | 171 / 183 |
| stomach | 99% | 1952.30 | 355 / 359 | 88% | 20.14 | 253 / 286 |
| intestine | 99% | 2375.90 | 952 / 966 | 88% | 20.75 | 463 / 527 |
| ovary | 99% | 3514.62 | 179 / 180 | 86% | 12.11 | 371 / 430 |
| uterus | 96% | 2890.03 | 164 / 170 | 89% | 24.20 | 409 / 459 |
| breast | 94% | 1539.04 | 430 / 459 | 78% | 12.55 | 868 / 1118 |
| pancreas | 66% | 835.22 | 216 / 328 | 94% | 36.84 | 167 / 178 |
| thymus | 85% | 1199.08 | 552 / 653 | 65% | 9.76 | 391 / 605 |
| adrenal gland | 89% | 1144.30 | 230 / 258 | 56% | 20.54 | 128 / 230 |
| skin | 63% | 730.60 | 1133 / 1809 | 72% | 12.63 | 341 / 472 |
| kidney | 73% | 905.52 | 65 / 89 | 61% | 5.19 | 546 / 901 |
| brain | 49% | 580.47 | 1293 / 2642 | 84% | 7.98 | 589 / 705 |
| prostate | 93% | 1601.41 | 227 / 245 | 22% | 1.34 | 108 / 502 |
| liver | 87% | 1190.29 | 196 / 226 | 26% | 10.15 | 104 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 47.50 | 29 / 29 |
| peripheral blood | 100% | 15641.84 | 929 / 929 | 0% | 0 | 0 / 0 |
| spleen | 100% | 12792.23 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 30.14 | 1 / 1 |
| adipose | 95% | 1480.38 | 1145 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 93% | 14.46 | 42 / 45 |
| blood vessel | 83% | 1142.43 | 1103 / 1335 | 0% | 0 | 0 / 0 |
| heart | 69% | 1087.02 | 595 / 861 | 0% | 0 | 0 / 0 |
| muscle | 61% | 803.22 | 490 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 18% | 1.09 | 14 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0002467 | Biological process | germinal center formation |
| GO_0051607 | Biological process | defense response to virus |
| GO_0043304 | Biological process | regulation of mast cell degranulation |
| GO_0002432 | Biological process | granuloma formation |
| GO_1903307 | Biological process | positive regulation of regulated secretory pathway |
| GO_0046903 | Biological process | secretion |
| GO_0006909 | Biological process | phagocytosis |
| GO_0043320 | Biological process | natural killer cell degranulation |
| GO_1900026 | Biological process | positive regulation of substrate adhesion-dependent cell spreading |
| GO_0045921 | Biological process | positive regulation of exocytosis |
| GO_0070382 | Cellular component | exocytic vesicle |
| GO_0035578 | Cellular component | azurophil granule lumen |
| GO_0005576 | Cellular component | extracellular region |
| GO_0016020 | Cellular component | membrane |
| GO_0055037 | Cellular component | recycling endosome |
| GO_0005764 | Cellular component | lysosome |
| GO_0033093 | Cellular component | Weibel-Palade body |
| GO_0005829 | Cellular component | cytosol |
| GO_0005770 | Cellular component | late endosome |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0031267 | Molecular function | small GTPase binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | UNC13D |
| Protein name | Protein unc-13 homolog D (Munc13-4) Unc-13 homolog D |
| Synonyms | |
| Description | FUNCTION: Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. . |
| Accessions | ENST00000585574.6 K7EM66 K7EQ37 ENST00000586108.1 A0A8V8TNE8 A0A8V8TNG5 ENST00000589670.5 ENST00000699512.1 ENST00000699510.1 K7EIH3 A0A8V8TQ40 K7ELN2 A0A8V8TNT8 ENST00000587504.6 ENST00000207549.9 [Q70J99-1] A0A8V8TPP8 K7EN29 ENST00000699511.1 ENST00000586519.1 ENST00000587105.1 K7EMK8 A0A8V8TPN4 ENST00000412096.6 [Q70J99-3] ENST00000590762.5 ENST00000699513.1 Q70J99 ENST00000586147.1 ENST00000592386.6 K7EN81 |
