ULK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0007224Biological processsmoothened signaling pathway
GO_0072537Biological processfibroblast activation
GO_0000045Biological processautophagosome assembly
GO_0034727Biological processpiecemeal microautophagy of the nucleus
GO_0045879Biological processnegative regulation of smoothened signaling pathway
GO_0042594Biological processresponse to starvation
GO_0045880Biological processpositive regulation of smoothened signaling pathway
GO_0010506Biological processregulation of autophagy
GO_0000422Biological processautophagy of mitochondrion
GO_0090398Biological processcellular senescence
GO_0061709Biological processreticulophagy
GO_0006914Biological processautophagy
GO_0046777Biological processprotein autophosphorylation
GO_0034045Cellular componentphagophore assembly site membrane
GO_0097542Cellular componentciliary tip
GO_0005829Cellular componentcytosol
GO_0005776Cellular componentautophagosome
GO_0000407Cellular componentphagophore assembly site
GO_0005737Cellular componentcytoplasm
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameULK3
Protein namenon-specific serine/threonine protein kinase (EC 2.7.11.1)
Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3)
Unc-51 like kinase 3
Synonyms
DescriptionFUNCTION: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. .

AccessionsENST00000562161.5
H3BTS3
H3BT78
ENST00000563301.5
H3BS27
ENST00000647587.1
H3BV76
H3BP85
ENST00000631115.1
ENST00000440863.7 [Q6PHR2-1]
ENST00000566631.5
H3BPN6
ENST00000565790.5
ENST00000568273.5
ENST00000569437.5 [Q6PHR2-3]
Q6PHR2
ENST00000568210.5
ENST00000565373.5
ENST00000568667.5 [Q6PHR2-4]
H3BMW8
ENST00000568679.1