Name | Number of supported studies | Average coverage | |
---|---|---|---|
basal cell | 8 studies | 26% ± 15% | |
epithelial cell | 6 studies | 36% ± 16% | |
conventional dendritic cell | 5 studies | 30% ± 13% | |
non-classical monocyte | 4 studies | 27% ± 8% | |
plasmacytoid dendritic cell | 4 studies | 28% ± 8% | |
classical monocyte | 3 studies | 22% ± 7% | |
hematopoietic precursor cell | 3 studies | 28% ± 8% | |
extravillous trophoblast | 3 studies | 19% ± 2% | |
placental villous trophoblast | 3 studies | 26% ± 6% | |
myeloid cell | 3 studies | 22% ± 7% | |
ciliated cell | 3 studies | 36% ± 15% | |
endothelial cell | 3 studies | 19% ± 4% | |
erythroblast | 3 studies | 27% ± 10% | |
macrophage | 3 studies | 25% ± 4% | |
dendritic cell | 3 studies | 40% ± 8% | |
goblet cell | 3 studies | 21% ± 3% | |
intestinal crypt stem cell | 3 studies | 21% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
stomach | 100% | 617.02 | 359 / 359 | 100% | 7.39 | 286 / 286 |
esophagus | 100% | 957.31 | 1443 / 1445 | 100% | 6.90 | 183 / 183 |
intestine | 100% | 709.07 | 966 / 966 | 99% | 6.93 | 524 / 527 |
bladder | 100% | 696.05 | 21 / 21 | 98% | 5.31 | 495 / 504 |
thymus | 100% | 1037.73 | 652 / 653 | 98% | 2.85 | 593 / 605 |
pancreas | 100% | 599.90 | 328 / 328 | 96% | 2.88 | 171 / 178 |
ovary | 95% | 281.14 | 171 / 180 | 100% | 4.66 | 430 / 430 |
uterus | 98% | 414.48 | 167 / 170 | 96% | 3.66 | 439 / 459 |
prostate | 100% | 642.76 | 245 / 245 | 94% | 2.60 | 470 / 502 |
lung | 99% | 598.74 | 571 / 578 | 91% | 2.77 | 1052 / 1155 |
adrenal gland | 100% | 1868.88 | 258 / 258 | 87% | 2.12 | 199 / 230 |
breast | 100% | 694.90 | 459 / 459 | 86% | 2.01 | 965 / 1118 |
brain | 99% | 618.92 | 2619 / 2642 | 71% | 1.29 | 504 / 705 |
kidney | 100% | 783.01 | 89 / 89 | 66% | 1.20 | 593 / 901 |
liver | 100% | 760.77 | 225 / 226 | 59% | 1.21 | 241 / 406 |
skin | 100% | 1336.64 | 1809 / 1809 | 56% | 1.02 | 266 / 472 |
adipose | 100% | 630.69 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 3.31 | 29 / 29 |
muscle | 100% | 1149.07 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 581.44 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 1.77 | 1 / 1 |
blood vessel | 100% | 621.39 | 1329 / 1335 | 0% | 0 | 0 / 0 |
heart | 94% | 598.25 | 807 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 82% | 2.20 | 37 / 45 |
peripheral blood | 64% | 430.06 | 590 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 56% | 0.79 | 45 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016567 | Biological process | protein ubiquitination |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0016579 | Biological process | protein deubiquitination |
GO_0043687 | Biological process | post-translational protein modification |
GO_0030163 | Biological process | protein catabolic process |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0008233 | Molecular function | peptidase activity |
GO_0019784 | Molecular function | deNEDDylase activity |
GO_0005515 | Molecular function | protein binding |
GO_0004843 | Molecular function | cysteine-type deubiquitinase activity |
GO_0043130 | Molecular function | ubiquitin binding |
Gene name | UCHL3 |
Protein name | Alternative protein UCHL3 Ubiquitin C-terminal hydrolase L3 Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3) |
Synonyms | |
Description | FUNCTION: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. . |
Accessions | P15374 ENST00000419068.1 ENST00000377595.8 L8EAH4 L8E899 Q5TBK7 |