UCHL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007628Biological processadult walking behavior
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0002176Biological processmale germ cell proliferation
GO_0002931Biological processresponse to ischemia
GO_0055001Biological processmuscle cell development
GO_0050905Biological processneuromuscular process
GO_0042755Biological processeating behavior
GO_0007412Biological processaxon target recognition
GO_0016579Biological processprotein deubiquitination
GO_0043407Biological processnegative regulation of MAP kinase activity
GO_0016241Biological processregulation of macroautophagy
GO_0019896Biological processaxonal transport of mitochondrion
GO_0045821Biological processpositive regulation of glycolytic process
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_1904115Cellular componentaxon cytoplasm
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005654Cellular componentnucleoplasm
GO_0043025Cellular componentneuronal cell body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0044306Cellular componentneuron projection terminus
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0031694Molecular functionalpha-2A adrenergic receptor binding
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding
GO_0008242Molecular functionomega peptidase activity

IV. Literature review

[source]
Gene nameUCHL1
Protein nameUbiquitin C-terminal hydrolase L1
Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12)
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1)
SynonymshCG_33087
DescriptionFUNCTION: Deubiquitinase that plays a role in the regulation of several processes such as maintenance of synaptic function, cardiac function, inflammatory response or osteoclastogenesis . Abrogates the ubiquitination of multiple proteins including WWTR1/TAZ, EGFR, HIF1A and beta-site amyloid precursor protein cleaving enzyme 1/BACE1 . In addition, recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin to maintain a stable pool of monoubiquitin that is a key requirement for the ubiquitin-proteasome and the autophagy-lysosome pathways . Regulates amyloid precursor protein/APP processing by promoting BACE1 degradation resulting in decreased amyloid beta production . Plays a role in the immune response by regulating the ability of MHC I molecules to reach cross-presentation compartments competent for generating Ag-MHC I complexes (By similarity). Mediates the 'Lys-48'-linked deubiquitination of the transcriptional coactivator WWTR1/TAZ leading to its stabilization and inhibition of osteoclastogenesis (By similarity). Deubiquitinates and stabilizes epidermal growth factor receptor EGFR to prevent its degradation and to activate its downstream mediators (By similarity). Modulates oxidative activity in skeletal muscle by regulating key mitochondrial oxidative proteins (By similarity). Enhances the activity of hypoxia-inducible factor 1-alpha/HIF1A by abrogateing its VHL E3 ligase-mediated ubiquitination and consequently inhibiting its degradation . .

AccessionsD6RF53
ENST00000505232.5
D6RE83
ENST00000514924.5
ENST00000512419.5
ENST00000503431.5
D6RJD9
ENST00000284440.9
ENST00000512788.1
A6NLJ7
ENST00000508768.5
D6R956
D6R974
P09936