UBXN2B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0061025Biological processmembrane fusion
GO_0046604Biological processpositive regulation of mitotic centrosome separation
GO_0007030Biological processGolgi organization
GO_0000132Biological processestablishment of mitotic spindle orientation
GO_0031468Biological processnuclear membrane reassembly
GO_1904780Biological processnegative regulation of protein localization to centrosome
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000045Biological processautophagosome assembly
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0031616Cellular componentspindle pole centrosome
GO_0005794Cellular componentGolgi apparatus
GO_0005634Cellular componentnucleus
GO_0043130Molecular functionubiquitin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUBXN2B
Protein nameUBX domain protein 2B
UBX domain-containing protein 2B (NSFL1 cofactor p37) (p97 cofactor p37)
Synonyms
DescriptionFUNCTION: Adapter protein required for Golgi and endoplasmic reticulum biogenesis . Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis . The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L . VCPIP1 is also required, but not its deubiquitinating activity . Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase . Also, regulates spindle orientation during mitosis . .

AccessionsENST00000521796.1
E5RJ36
Q14CS0
ENST00000399598.7
E5RGJ4
ENST00000520732.5
ENST00000523409.5
H0YAX6