UBIAD1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of UBIAD1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of UBIAD1 at tissue level.

III. Associated gene sets

GO_0009234Biological processmenaquinone biosynthetic process
GO_0032194Biological processubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate
GO_0042371Biological processvitamin K biosynthetic process
GO_0098869Biological processcellular oxidant detoxification
GO_0006744Biological processubiquinone biosynthetic process
GO_0042373Biological processvitamin K metabolic process
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0031966Cellular componentmitochondrial membrane
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0002083Molecular function4-hydroxybenzoate decaprenyltransferase activity
GO_0016209Molecular functionantioxidant activity
GO_0005515Molecular functionprotein binding
GO_0004659Molecular functionprenyltransferase activity

IV. Literature review

[source]
Gene nameUBIAD1
Protein nameUbiA prenyltransferase domain-containing protein 1 (EC 2.5.1.39)
UbiA prenyltransferase domain containing 1
UbiA prenyltransferase domain-containing protein 1 (EC 2.5.1.-) (EC 2.5.1.39) (Transitional epithelial response protein 1)
SynonymsTERE1
DescriptionFUNCTION: Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10 . MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development . Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4 . Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system . Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress . .

AccessionsENST00000376810.6 [Q9Y5Z9-1]
ENST00000376804.2 [Q9Y5Z9-2]
ENST00000483738.1
R4GN21
ENST00000486588.6
Q9Y5Z9
R4GNE3