UBE2T report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0070979Biological processprotein K11-linked ubiquitination
GO_0000209Biological processprotein polyubiquitination
GO_0006974Biological processDNA damage response
GO_0051865Biological processprotein autoubiquitination
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0044314Biological processprotein K27-linked ubiquitination
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0035519Biological processprotein K29-linked ubiquitination
GO_0006513Biological processprotein monoubiquitination
GO_0085020Biological processprotein K6-linked ubiquitination
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0003682Molecular functionchromatin binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005524Molecular functionATP binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0061631Molecular functionubiquitin conjugating enzyme activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUBE2T
Protein nameUbiquitin conjugating enzyme E2 T (Ubiquitin-conjugating enzyme E2T (Putative), isoform CRA_c)
Ubiquitin conjugating enzyme E2 T
Ubiquitin conjugating enzyme E2 T (Ubiquitin-conjugating enzyme E2T (Putative), isoform CRA_d)
Ubiquitin-conjugating enzyme E2 T (EC 2.3.2.23) (Cell proliferation-inducing gene 50 protein) (E2 ubiquitin-conjugating enzyme T) (Ubiquitin carrier protein T) (Ubiquitin-protein ligase T)
SynonymsPIG50
hCG_2027327
HSPC150
DescriptionFUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway . Also mediates monoubiquitination of FANCL and FANCI . May contribute to ubiquitination and degradation of BRCA1 . In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination . .

AccessionsENST00000646651.1
ENST00000699429.1
ENST00000699423.1
A0A8V8TN93
ENST00000699425.1
A0A8V8TNE2
A0A8V8TQ15
ENST00000699424.1
A0A8V8TPM9
Q9NPD8
A0A2R8Y812
ENST00000643045.1
ENST00000699428.1