UBD report

I. Expression across cell types

Insufficient scRNA-seq data for expression of UBD at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of UBD at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0034612Biological processresponse to tumor necrosis factor
GO_0034341Biological processresponse to type II interferon
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0006508Biological processproteolysis
GO_0043011Biological processmyeloid dendritic cell differentiation
GO_0070842Biological processaggresome assembly
GO_0032446Biological processprotein modification by small protein conjugation
GO_1901990Biological processregulation of mitotic cell cycle phase transition
GO_0043065Biological processpositive regulation of apoptotic process
GO_0005654Cellular componentnucleoplasm
GO_0001650Cellular componentfibrillar center
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0016235Cellular componentaggresome
GO_0005634Cellular componentnucleus
GO_0070628Molecular functionproteasome binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUBD
Protein nameUbiquitin D (Diubiquitin) (Ubiquitin-like protein FAT10)
UBD (Ubiquitin D)
SynonymsFAT10
DescriptionFUNCTION: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN). .

AccessionsENST00000383641.2
O15205
ENST00000429935.2
ENST00000421519.2
ENST00000377050.5
A0A0G2JH67
ENST00000414436.2
ENST00000383547.3
ENST00000432676.2