UBAC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0051604Biological processprotein maturation
GO_0000151Cellular componentubiquitin ligase complex
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005794Cellular componentGolgi apparatus
GO_0005886Cellular componentplasma membrane
GO_0031593Molecular functionpolyubiquitin modification-dependent protein binding
GO_0070628Molecular functionproteasome binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUBAC1
Protein nameUbiquitin-associated domain-containing protein 1 (UBA domain-containing protein 1) (Glialblastoma cell differentiation-related protein 1) (Kip1 ubiquitination-promoting complex protein 2)
SynonymsKPC2
UBADC1
GBDR1
DescriptionFUNCTION: Non-catalytic component of the KPC complex, a E3 ubiquitin-protein ligase complex that mediates polyubiquitination of target proteins, such as CDKN1B and NFKB1 . The KPC complex catalyzes polyubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle . The KPC complex also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B by catalyzing ubiquitination of the NFKB1 p105 precursor . Within the KPC complex, UBAC1 acts as an adapter that promotes the transfer of target proteins that have been polyubiquitinated by RNF123/KPC1 to the 26S proteasome . .

AccessionsENST00000371756.4
Q9BSL1