UBA7 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of UBA7 at tissue level.

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0016567Biological processprotein ubiquitination
GO_0032020Biological processISG15-protein conjugation
GO_0036211Biological processprotein modification process
GO_0045087Biological processinnate immune response
GO_0019941Biological processmodification-dependent protein catabolic process
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0019782Molecular functionISG15 activating enzyme activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUBA7
Protein nameUbiquitin-like modifier-activating enzyme 7 (Ubiquitin-activating enzyme 7) (EC 6.2.1.-) (D8) (Ubiquitin-activating enzyme E1 homolog)
SynonymsUBE2
UBE1L
DescriptionFUNCTION: E1-activating enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of ISG15 to additional interferon stimulated proteins (ISGs) as well as other cellular proteins such as P53 in a process termed protein ISGylation . Plays an essential role in antiviral immunity together with ISG15 by restricting the replication of many viruses including rabies virus, influenza virus, sindbis virus, rotavirus or human cytomegalovirus . For example, ISG15 modification of influenza A protein NS1 disrupts the association of the NS1 with importin-alpha leading to NS1 nuclear import inhibition . ISGylation of human cytomegalovirs protein UL26 regulates its stability and inhibits its activities to suppress NF-kappa-B signaling . .

AccessionsP41226
ENST00000333486.4