Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 8 studies | 23% ± 8% | |
| plasma cell | 5 studies | 28% ± 13% | |
| endothelial cell | 5 studies | 24% ± 5% | |
| plasmablast | 4 studies | 42% ± 23% | |
| astrocyte | 4 studies | 28% ± 10% | |
| fibroblast | 3 studies | 22% ± 2% | |
| ciliated cell | 3 studies | 19% ± 3% | |
| GABAergic neuron | 3 studies | 41% ± 5% | |
| glutamatergic neuron | 3 studies | 52% ± 5% | |
| oligodendrocyte precursor cell | 3 studies | 28% ± 9% | |
| dendritic cell | 3 studies | 21% ± 3% | |
| basal cell | 3 studies | 22% ± 0% | |
| plasmacytoid dendritic cell | 3 studies | 24% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 100% | 1912.29 | 21 / 21 | 100% | 15.62 | 504 / 504 |
| esophagus | 100% | 1874.14 | 1445 / 1445 | 100% | 16.90 | 183 / 183 |
| kidney | 100% | 2833.46 | 89 / 89 | 100% | 29.04 | 901 / 901 |
| lung | 100% | 2161.16 | 578 / 578 | 100% | 18.08 | 1155 / 1155 |
| ovary | 100% | 2287.19 | 180 / 180 | 100% | 10.43 | 430 / 430 |
| prostate | 100% | 2936.58 | 245 / 245 | 100% | 24.55 | 502 / 502 |
| stomach | 100% | 2164.40 | 359 / 359 | 100% | 13.91 | 286 / 286 |
| uterus | 100% | 2086.59 | 170 / 170 | 100% | 17.87 | 459 / 459 |
| breast | 100% | 2121.17 | 459 / 459 | 100% | 20.96 | 1117 / 1118 |
| brain | 100% | 1921.69 | 2638 / 2642 | 100% | 23.60 | 705 / 705 |
| thymus | 100% | 2776.97 | 653 / 653 | 100% | 18.72 | 604 / 605 |
| liver | 100% | 2213.40 | 226 / 226 | 100% | 13.20 | 405 / 406 |
| intestine | 100% | 2017.14 | 966 / 966 | 100% | 14.54 | 525 / 527 |
| pancreas | 100% | 3372.38 | 328 / 328 | 99% | 14.73 | 177 / 178 |
| adrenal gland | 100% | 3839.24 | 258 / 258 | 99% | 15.08 | 228 / 230 |
| skin | 100% | 2062.91 | 1809 / 1809 | 96% | 14.97 | 453 / 472 |
| adipose | 100% | 2005.65 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 16.82 | 29 / 29 |
| spleen | 100% | 3086.61 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 18.74 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 5.66 | 1 / 1 |
| muscle | 100% | 1676.79 | 802 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2025.08 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 1869.45 | 854 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 69% | 5.28 | 55 / 80 |
| peripheral blood | 44% | 888.32 | 408 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0034976 | Biological process | response to endoplasmic reticulum stress |
| GO_0033146 | Biological process | regulation of intracellular estrogen receptor signaling pathway |
| GO_1990592 | Biological process | protein K69-linked ufmylation |
| GO_0050905 | Biological process | neuromuscular process |
| GO_0071569 | Biological process | protein ufmylation |
| GO_0030218 | Biological process | erythrocyte differentiation |
| GO_0061709 | Biological process | reticulophagy |
| GO_0030219 | Biological process | megakaryocyte differentiation |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0005634 | Cellular component | nucleus |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0071566 | Molecular function | UFM1 activating enzyme activity |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | UBA5 |
| Protein name | UFM1-activating enzyme Ubiquitin like modifier activating enzyme 5 Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) Ubiquitin-like modifier-activating enzyme 5 (UFM1-activating enzyme) Ubiquitin-like modifier-activating enzyme 5 |
| Synonyms | UBE1DC1 |
| Description | FUNCTION: E1-like enzyme which specifically catalyzes the first step in ufmylation . Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP . Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer . Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding . Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism . Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress . Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity). . |
| Accessions | ENST00000489361.1 ENST00000464068.5 D6RJC9 ENST00000683741.1 ENST00000473651.5 ENST00000493720.6 ENST00000264991.8 [Q9GZZ9-2] ENST00000356232.10 [Q9GZZ9-1] C9J5W5 ENST00000505777.5 C9JRV9 Q9GZZ9 E7EWE1 ENST00000494238.6 [Q9GZZ9-2] E7EQ61 A0A804HJ86 ENST00000468022.5 C9J0F6 |