I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 3 studies | 31% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 3 studies | 31% ± 6% |
Insufficient scRNA-seq data for expression of TXNRD3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 343.53 | 245 / 245 | 99% | 9.51 | 499 / 502 |
| kidney | 100% | 292.74 | 89 / 89 | 99% | 8.45 | 890 / 901 |
| pancreas | 99% | 239.55 | 325 / 328 | 99% | 7.71 | 177 / 178 |
| liver | 100% | 348.65 | 226 / 226 | 99% | 7.12 | 400 / 406 |
| thymus | 100% | 441.64 | 653 / 653 | 99% | 8.70 | 596 / 605 |
| breast | 100% | 464.35 | 459 / 459 | 98% | 11.20 | 1100 / 1118 |
| bladder | 100% | 376.19 | 21 / 21 | 98% | 8.96 | 493 / 504 |
| skin | 100% | 418.18 | 1809 / 1809 | 97% | 9.12 | 457 / 472 |
| uterus | 100% | 498.62 | 170 / 170 | 97% | 9.87 | 443 / 459 |
| lung | 99% | 332.46 | 572 / 578 | 97% | 10.40 | 1116 / 1155 |
| ovary | 100% | 579.65 | 180 / 180 | 93% | 6.34 | 402 / 430 |
| intestine | 99% | 270.69 | 956 / 966 | 94% | 7.01 | 495 / 527 |
| adrenal gland | 100% | 388.84 | 258 / 258 | 92% | 4.72 | 211 / 230 |
| brain | 92% | 121.48 | 2426 / 2642 | 99% | 7.70 | 699 / 705 |
| esophagus | 100% | 354.50 | 1443 / 1445 | 90% | 7.06 | 164 / 183 |
| stomach | 100% | 293.53 | 359 / 359 | 86% | 5.73 | 246 / 286 |
| adipose | 100% | 401.99 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 100% | 329.42 | 803 / 803 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 14.66 | 1 / 1 |
| blood vessel | 100% | 316.39 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 99% | 219.88 | 239 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 7.96 | 44 / 45 |
| eye | 0% | 0 | 0 / 0 | 94% | 6.17 | 75 / 80 |
| heart | 92% | 199.80 | 794 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 14% | 0.35 | 4 / 29 |
| peripheral blood | 1% | 1.38 | 12 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0045454 | Biological process | cell redox homeostasis |
| GO_0007283 | Biological process | spermatogenesis |
| GO_0030154 | Biological process | cell differentiation |
| GO_0098869 | Biological process | cellular oxidant detoxification |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0050660 | Molecular function | flavin adenine dinucleotide binding |
| GO_0004791 | Molecular function | thioredoxin-disulfide reductase (NADPH) activity |
| Gene name | TXNRD3 |
| Protein name | thioredoxin-disulfide reductase (EC 1.8.1.9) Thioredoxin reductase 3 (EC 1.8.1.9) (Thioredoxin and glutathione reductase) (Thioredoxin reductase TR2) |
| Synonyms | TGR TRXR3 |
| Description | FUNCTION: Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity). . |
| Accessions | ENST00000524230.9 Q86VQ6 H0YBI6 ENST00000523403.3 ENST00000524230 H0YBQ0 |
