TXNDC2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TXNDC2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TXNDC2 at tissue level.

III. Associated gene sets

GO_0045454Biological processcell redox homeostasis
GO_0007283Biological processspermatogenesis
GO_0098869Biological processcellular oxidant detoxification
GO_0030154Biological processcell differentiation
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding
GO_0004791Molecular functionthioredoxin-disulfide reductase (NADPH) activity

IV. Literature review

[source]
Gene nameTXNDC2
Protein nameThioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1)
Thioredoxin domain containing 2
SynonymsSPTRX
SPTRX1
DescriptionFUNCTION: Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.

AccessionsQ86VQ3
F5H6S7
J3QSG5
ENST00000306084.6 [Q86VQ3-1]
ENST00000536353.2
ENST00000357775.6 [Q86VQ3-2]
ENST00000584255.1