TWSG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030511Biological processpositive regulation of transforming growth factor beta receptor signaling pathway
GO_2000515Biological processnegative regulation of CD4-positive, alpha-beta T cell activation
GO_0030097Biological processhemopoiesis
GO_0030900Biological processforebrain development
GO_0030510Biological processregulation of BMP signaling pathway
GO_0002062Biological processchondrocyte differentiation
GO_0060391Biological processpositive regulation of SMAD protein signal transduction
GO_0030514Biological processnegative regulation of BMP signaling pathway
GO_0030509Biological processBMP signaling pathway
GO_0001707Biological processmesoderm formation
GO_0045668Biological processnegative regulation of osteoblast differentiation
GO_0030513Biological processpositive regulation of BMP signaling pathway
GO_0001818Biological processnegative regulation of cytokine production
GO_0043010Biological processcamera-type eye development
GO_0001503Biological processossification
GO_0007435Biological processsalivary gland morphogenesis
GO_2000562Biological processnegative regulation of CD4-positive, alpha-beta T cell proliferation
GO_0005615Cellular componentextracellular space
GO_0008201Molecular functionheparin binding
GO_0050431Molecular functiontransforming growth factor beta binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTWSG1
Protein nameTwisted gastrulation BMP signaling modulator 1
Twisted gastrulation protein homolog 1
SynonymsTSG
PSEC0250
DescriptionFUNCTION: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity). .

AccessionsQ9GZX9
J3QS03
ENST00000581641.1
ENST00000262120.10 [Q9GZX9-1]
ENST00000583147.5 [Q9GZX9-2]