TUBB3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000278Biological processmitotic cell cycle
GO_1990791Biological processdorsal root ganglion development
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0038007Biological processnetrin-activated signaling pathway
GO_0007411Biological processaxon guidance
GO_0005874Cellular componentmicrotubule
GO_0072686Cellular componentmitotic spindle
GO_0070062Cellular componentextracellular exosome
GO_0043025Cellular componentneuronal cell body
GO_0045171Cellular componentintercellular bridge
GO_0030425Cellular componentdendrite
GO_0030175Cellular componentfilopodium
GO_0071944Cellular componentcell periphery
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0030426Cellular componentgrowth cone
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0030027Cellular componentlamellipodium
GO_0005634Cellular componentnucleus
GO_0042277Molecular functionpeptide binding
GO_0005200Molecular functionstructural constituent of cytoskeleton
GO_0005525Molecular functionGTP binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_1990890Molecular functionnetrin receptor binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameTUBB3
Protein nameHCG1983504, isoform CRA_e (Tubulin beta 3 class III)
Tubulin beta 3 class III
HCG1983504, isoform CRA_b (Tubulin beta 3 class III)
HCG1983504, isoform CRA_c (Tubulin beta 3 class III)
Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III)
Tubulin beta-3 chain
HCG1983504, isoform CRA_d (Tubulin beta 3 class III)
Tubulin beta chain
SynonymshCG_1983504
TUBB4
DescriptionFUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers . Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms . Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin . TUBB3 plays a critical role in proper axon guidance and maintenance . Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion . Plays a role in dorsal root ganglion axon projection towards the spinal cord . .

FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. .

FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. .

FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. .

AccessionsENST00000555576.5
ENST00000553656.5
ENST00000554444.5 [Q13509-2]
G3V3W7
ENST00000557490.5
ENST00000554336.5
ENST00000557262.5
G3V542
ENST00000556565.5
G3V4U2
Q13509
ENST00000555609.5
ENST00000553967.1
G3V2R8
Q3ZCR3
G3V5W4
G3V3J6
G3V3R4
ENST00000556536.5
Q9BV28
G3V2A3
ENST00000555810.5
ENST00000315491.12 [Q13509-1]
G3V2N6