Name | Number of supported studies | Average coverage | |
---|---|---|---|
neuron | 5 studies | 50% ± 25% | |
retinal ganglion cell | 4 studies | 63% ± 27% | |
glutamatergic neuron | 4 studies | 35% ± 18% | |
retina horizontal cell | 3 studies | 24% ± 4% | |
GABAergic neuron | 3 studies | 35% ± 14% | |
interneuron | 3 studies | 37% ± 11% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 3 studies | 33% ± 15% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 99% | 10522.47 | 2610 / 2642 | 54% | 1.13 | 383 / 705 |
adrenal gland | 72% | 1392.89 | 185 / 258 | 55% | 1.34 | 127 / 230 |
skin | 36% | 1529.01 | 645 / 1809 | 42% | 0.84 | 196 / 472 |
intestine | 58% | 952.96 | 560 / 966 | 15% | 0.29 | 79 / 527 |
esophagus | 22% | 263.58 | 311 / 1445 | 20% | 0.44 | 36 / 183 |
stomach | 23% | 319.11 | 83 / 359 | 14% | 0.26 | 41 / 286 |
bladder | 14% | 299.67 | 3 / 21 | 20% | 0.44 | 103 / 504 |
lung | 11% | 157.41 | 64 / 578 | 21% | 0.49 | 248 / 1155 |
kidney | 17% | 328.65 | 15 / 89 | 12% | 0.21 | 105 / 901 |
pancreas | 4% | 72.43 | 14 / 328 | 20% | 0.29 | 35 / 178 |
ovary | 10% | 132.88 | 18 / 180 | 11% | 0.18 | 48 / 430 |
uterus | 4% | 66.97 | 7 / 170 | 15% | 0.30 | 67 / 459 |
breast | 4% | 53.92 | 18 / 459 | 8% | 0.14 | 84 / 1118 |
adipose | 10% | 122.64 | 118 / 1204 | 0% | 0 | 0 / 0 |
prostate | 8% | 97.00 | 20 / 245 | 0% | 0.01 | 2 / 502 |
heart | 8% | 91.03 | 67 / 861 | 0% | 0 | 0 / 0 |
blood vessel | 6% | 75.93 | 82 / 1335 | 0% | 0 | 0 / 0 |
thymus | 4% | 46.46 | 28 / 653 | 1% | 0.02 | 6 / 605 |
liver | 1% | 15.72 | 2 / 226 | 3% | 0.07 | 13 / 406 |
eye | 0% | 0 | 0 / 0 | 4% | 0.07 | 3 / 80 |
lymph node | 0% | 0 | 0 / 0 | 3% | 0.04 | 1 / 29 |
spleen | 1% | 9.75 | 2 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 3.47 | 2 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0000278 | Biological process | mitotic cell cycle |
GO_1990791 | Biological process | dorsal root ganglion development |
GO_0000226 | Biological process | microtubule cytoskeleton organization |
GO_0038007 | Biological process | netrin-activated signaling pathway |
GO_0007411 | Biological process | axon guidance |
GO_0005874 | Cellular component | microtubule |
GO_0072686 | Cellular component | mitotic spindle |
GO_0070062 | Cellular component | extracellular exosome |
GO_0043025 | Cellular component | neuronal cell body |
GO_0045171 | Cellular component | intercellular bridge |
GO_0030425 | Cellular component | dendrite |
GO_0030175 | Cellular component | filopodium |
GO_0071944 | Cellular component | cell periphery |
GO_0015630 | Cellular component | microtubule cytoskeleton |
GO_0030426 | Cellular component | growth cone |
GO_0005737 | Cellular component | cytoplasm |
GO_0030424 | Cellular component | axon |
GO_0030027 | Cellular component | lamellipodium |
GO_0005634 | Cellular component | nucleus |
GO_0042277 | Molecular function | peptide binding |
GO_0005200 | Molecular function | structural constituent of cytoskeleton |
GO_0005525 | Molecular function | GTP binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0005515 | Molecular function | protein binding |
GO_1990890 | Molecular function | netrin receptor binding |
GO_0003924 | Molecular function | GTPase activity |
Gene name | TUBB3 |
Protein name | HCG1983504, isoform CRA_e (Tubulin beta 3 class III) Tubulin beta 3 class III HCG1983504, isoform CRA_b (Tubulin beta 3 class III) HCG1983504, isoform CRA_c (Tubulin beta 3 class III) Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) Tubulin beta-3 chain HCG1983504, isoform CRA_d (Tubulin beta 3 class III) Tubulin beta chain |
Synonyms | hCG_1983504 TUBB4 |
Description | FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers . Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms . Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin . TUBB3 plays a critical role in proper axon guidance and maintenance . Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion . Plays a role in dorsal root ganglion axon projection towards the spinal cord . . FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. . FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. . FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. . |
Accessions | ENST00000555576.5 ENST00000553656.5 ENST00000554444.5 [Q13509-2] G3V3W7 ENST00000557490.5 ENST00000554336.5 ENST00000557262.5 G3V542 ENST00000556565.5 G3V4U2 Q13509 ENST00000555609.5 ENST00000553967.1 G3V2R8 Q3ZCR3 G3V5W4 G3V3J6 G3V3R4 ENST00000556536.5 Q9BV28 G3V2A3 ENST00000555810.5 ENST00000315491.12 [Q13509-1] G3V2N6 |