TUBB2B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902669Biological processpositive regulation of axon guidance
GO_0050804Biological processmodulation of chemical synaptic transmission
GO_0000278Biological processmitotic cell cycle
GO_0007017Biological processmicrotubule-based process
GO_0001764Biological processneuron migration
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0021987Biological processcerebral cortex development
GO_1990403Biological processembryonic brain development
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0005874Cellular componentmicrotubule
GO_0072686Cellular componentmitotic spindle
GO_0045171Cellular componentintercellular bridge
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005200Molecular functionstructural constituent of cytoskeleton
GO_0005525Molecular functionGTP binding
GO_0046872Molecular functionmetal ion binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameTUBB2B
Protein nameTubulin beta-2B chain
Tubulin beta chain
Synonyms
DescriptionFUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers . Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts . Implicated in neuronal migration . .

FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. .

AccessionsQ9BVA1
A1L195
ENST00000259818.8