Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retinal cone cell | 6 studies | 42% ± 16% | |
| retinal rod cell | 6 studies | 35% ± 13% | |
| ciliated cell | 6 studies | 25% ± 9% | |
| glutamatergic neuron | 6 studies | 43% ± 25% | |
| epithelial cell | 5 studies | 22% ± 5% | |
| astrocyte | 5 studies | 32% ± 10% | |
| GABAergic neuron | 4 studies | 46% ± 17% | |
| oligodendrocyte precursor cell | 4 studies | 30% ± 8% | |
| interneuron | 4 studies | 41% ± 25% | |
| endothelial cell | 3 studies | 24% ± 5% | |
| ependymal cell | 3 studies | 45% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| adrenal gland | 100% | 3617.27 | 258 / 258 | 100% | 40.81 | 230 / 230 |
| prostate | 100% | 1667.58 | 245 / 245 | 100% | 18.11 | 502 / 502 |
| ovary | 100% | 4751.01 | 180 / 180 | 100% | 11.51 | 429 / 430 |
| breast | 100% | 1261.52 | 458 / 459 | 99% | 18.31 | 1108 / 1118 |
| brain | 99% | 1167.68 | 2605 / 2642 | 100% | 10.73 | 702 / 705 |
| thymus | 100% | 2389.64 | 653 / 653 | 98% | 18.81 | 591 / 605 |
| bladder | 100% | 1380.76 | 21 / 21 | 97% | 10.16 | 489 / 504 |
| pancreas | 98% | 571.26 | 322 / 328 | 98% | 10.85 | 175 / 178 |
| skin | 99% | 977.34 | 1798 / 1809 | 97% | 12.30 | 457 / 472 |
| intestine | 100% | 1056.82 | 965 / 966 | 96% | 7.60 | 505 / 527 |
| esophagus | 100% | 1033.77 | 1444 / 1445 | 95% | 8.30 | 173 / 183 |
| lung | 96% | 695.99 | 554 / 578 | 98% | 8.82 | 1133 / 1155 |
| stomach | 97% | 638.03 | 350 / 359 | 96% | 7.15 | 275 / 286 |
| kidney | 100% | 790.11 | 89 / 89 | 93% | 6.99 | 842 / 901 |
| uterus | 100% | 1314.44 | 170 / 170 | 93% | 8.17 | 426 / 459 |
| liver | 99% | 637.50 | 223 / 226 | 67% | 3.87 | 274 / 406 |
| spleen | 100% | 699.24 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 5.54 | 1 / 1 |
| adipose | 100% | 811.58 | 1202 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 1070.42 | 1326 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 93% | 12.49 | 74 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 89% | 6.02 | 40 / 45 |
| heart | 85% | 434.28 | 733 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 34% | 1.38 | 10 / 29 |
| muscle | 11% | 34.64 | 90 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 10% | 31.40 | 93 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_1905515 | Biological process | non-motile cilium assembly |
| GO_0060271 | Biological process | cilium assembly |
| GO_0045198 | Biological process | establishment of epithelial cell apical/basal polarity |
| GO_0072659 | Biological process | protein localization to plasma membrane |
| GO_0045444 | Biological process | fat cell differentiation |
| GO_0032880 | Biological process | regulation of protein localization |
| GO_0035264 | Biological process | multicellular organism growth |
| GO_0060122 | Biological process | inner ear receptor cell stereocilium organization |
| GO_0007608 | Biological process | sensory perception of smell |
| GO_0021772 | Biological process | olfactory bulb development |
| GO_0050893 | Biological process | sensory processing |
| GO_0061326 | Biological process | renal tubule development |
| GO_1903251 | Biological process | multi-ciliated epithelial cell differentiation |
| GO_0001736 | Biological process | establishment of planar polarity |
| GO_0051492 | Biological process | regulation of stress fiber assembly |
| GO_0015031 | Biological process | protein transport |
| GO_0060219 | Biological process | camera-type eye photoreceptor cell differentiation |
| GO_0007411 | Biological process | axon guidance |
| GO_0048560 | Biological process | establishment of anatomical structure orientation |
| GO_0032391 | Cellular component | photoreceptor connecting cilium |
| GO_0034451 | Cellular component | centriolar satellite |
| GO_0034464 | Cellular component | BBSome |
| GO_0005813 | Cellular component | centrosome |
| GO_0060170 | Cellular component | ciliary membrane |
| GO_0097730 | Cellular component | non-motile cilium |
| GO_0005929 | Cellular component | cilium |
| GO_0005829 | Cellular component | cytosol |
| GO_0036064 | Cellular component | ciliary basal body |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TTC8 |
| Protein name | Tetratricopeptide repeat domain 8 isoform 5 Full-length cDNA clone CS0DA007YG23 of Neuroblastoma of Homo sapiens (human) (Tetratricopeptide repeat domain 8) Tetratricopeptide repeat domain 8, isoform CRA_a (cDNA FLJ36572 fis, clone TRACH2012298, highly similar to Tetratricopeptide repeat protein 8) Tetratricopeptide repeat domain 8 (Tetratricopeptide repeat domain 8, isoform CRA_c) Tetratricopeptide repeat domain 8 (Tetratricopeptide repeat domain 8, isoform CRA_g) Tetratricopeptide repeat domain 8 Tetratricopeptide repeat domain 8 isoform 6 Tetratricopeptide repeat protein 8 (TPR repeat protein 8) (Bardet-Biedl syndrome 8 protein) Tetratricopeptide repeat domain 8 isoform 4 |
| Synonyms | BBS8 hCG_21081 |
| Description | FUNCTION: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. . |
| Accessions | G3V2W6 Q86U25 A0A0S2Z625 B3KSL8 ENST00000346301.8 A0A0C4DGX9 ENST00000556651.5 Q8TAM2 ENST00000555057.5 G3V2Z9 ENST00000557580.3 ENST00000380656.7 [Q8TAM2-4] ENST00000553718.1 H0YJQ3 ENST00000354441.10 [Q8TAM2-2] ENST00000556077.5 ENST00000338104.10 A0A0S2Z5V9 A0A0S2Z666 ENST00000554686.5 ENST00000622513.4 G3V324 A0A0C4DGY3 H0YJX0 A0A0C4DGH8 |
