Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 9 studies | 25% ± 10% | |
capillary endothelial cell | 7 studies | 25% ± 8% | |
type I pneumocyte | 6 studies | 24% ± 4% | |
kidney loop of Henle epithelial cell | 6 studies | 26% ± 5% | |
epithelial cell | 6 studies | 32% ± 15% | |
epithelial cell of proximal tubule | 4 studies | 34% ± 18% | |
glomerular endothelial cell | 3 studies | 20% ± 2% | |
kidney distal convoluted tubule epithelial cell | 3 studies | 37% ± 10% | |
vein endothelial cell | 3 studies | 16% ± 1% | |
parietal epithelial cell | 3 studies | 30% ± 10% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
kidney | 3 studies | 16% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
kidney | 100% | 3435.28 | 89 / 89 | 96% | 145.18 | 861 / 901 |
intestine | 99% | 1801.79 | 954 / 966 | 92% | 38.39 | 484 / 527 |
thymus | 100% | 2692.21 | 653 / 653 | 87% | 31.38 | 524 / 605 |
pancreas | 97% | 664.01 | 318 / 328 | 85% | 23.99 | 152 / 178 |
stomach | 95% | 1046.33 | 340 / 359 | 84% | 28.57 | 239 / 286 |
lung | 100% | 2532.69 | 578 / 578 | 76% | 27.26 | 882 / 1155 |
prostate | 93% | 594.66 | 228 / 245 | 79% | 18.52 | 396 / 502 |
brain | 71% | 315.64 | 1883 / 2642 | 91% | 40.83 | 642 / 705 |
bladder | 90% | 982.33 | 19 / 21 | 72% | 27.76 | 361 / 504 |
adrenal gland | 100% | 5997.68 | 257 / 258 | 62% | 89.53 | 142 / 230 |
liver | 100% | 1077.04 | 225 / 226 | 60% | 16.56 | 244 / 406 |
breast | 100% | 939.13 | 457 / 459 | 51% | 13.35 | 574 / 1118 |
uterus | 93% | 773.11 | 158 / 170 | 43% | 13.32 | 196 / 459 |
esophagus | 84% | 455.61 | 1219 / 1445 | 43% | 9.22 | 78 / 183 |
ovary | 25% | 115.79 | 45 / 180 | 87% | 36.39 | 372 / 430 |
spleen | 100% | 1655.34 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 17.34 | 1 / 1 |
blood vessel | 100% | 1532.95 | 1329 / 1335 | 0% | 0 | 0 / 0 |
adipose | 99% | 1116.21 | 1196 / 1204 | 0% | 0 | 0 / 0 |
heart | 97% | 1678.52 | 832 / 861 | 0% | 0 | 0 / 0 |
skin | 14% | 57.05 | 256 / 1809 | 8% | 1.33 | 39 / 472 |
tonsil | 0% | 0 | 0 / 0 | 20% | 3.29 | 9 / 45 |
peripheral blood | 17% | 292.74 | 155 / 929 | 0% | 0 | 0 / 0 |
muscle | 7% | 24.78 | 58 / 803 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 3% | 0.43 | 1 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0001525 | Biological process | angiogenesis |
GO_0010842 | Biological process | retina layer formation |
GO_0110135 | Biological process | Norrin signaling pathway |
GO_0035633 | Biological process | maintenance of blood-brain barrier |
GO_0045765 | Biological process | regulation of angiogenesis |
GO_0007166 | Biological process | cell surface receptor signaling pathway |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0042813 | Molecular function | Wnt receptor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | TSPAN12 |
Protein name | Tetraspanin-12 (Tspan-12) (Tetraspan NET-2) (Transmembrane 4 superfamily member 12) Tetraspanin 12 |
Synonyms | TM4SF12 NET2 UNQ774/PRO1568 |
Description | FUNCTION: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activates the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity. . |
Accessions | C9JC05 H7C0X9 ENST00000430985.1 ENST00000450414.5 ENST00000222747.8 [O95859-1] ENST00000424710.5 ENST00000433758.5 ENST00000441017.5 C9IZ82 C9JQM0 ENST00000415871.5 [O95859-1] O95859 C9J9U1 |