TSPAN12 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0010842Biological processretina layer formation
GO_0110135Biological processNorrin signaling pathway
GO_0035633Biological processmaintenance of blood-brain barrier
GO_0045765Biological processregulation of angiogenesis
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0042813Molecular functionWnt receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTSPAN12
Protein nameTetraspanin-12 (Tspan-12) (Tetraspan NET-2) (Transmembrane 4 superfamily member 12)
Tetraspanin 12
SynonymsTM4SF12
NET2
UNQ774/PRO1568
DescriptionFUNCTION: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activates the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity. .

AccessionsC9JC05
H7C0X9
ENST00000430985.1
ENST00000450414.5
ENST00000222747.8 [O95859-1]
ENST00000424710.5
ENST00000433758.5
ENST00000441017.5
C9IZ82
C9JQM0
ENST00000415871.5 [O95859-1]
O95859
C9J9U1