TSKU report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TSKU at tissue level.

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0010468Biological processregulation of gene expression
GO_0021766Biological processhippocampus development
GO_1904761Biological processnegative regulation of myofibroblast differentiation
GO_0008203Biological processcholesterol metabolic process
GO_0060122Biological processinner ear receptor cell stereocilium organization
GO_0032911Biological processnegative regulation of transforming growth factor beta1 production
GO_0003431Biological processgrowth plate cartilage chondrocyte development
GO_0042060Biological processwound healing
GO_0061073Biological processciliary body morphogenesis
GO_0030178Biological processnegative regulation of Wnt signaling pathway
GO_0042635Biological processpositive regulation of hair cycle
GO_0021960Biological processanterior commissure morphogenesis
GO_0010977Biological processnegative regulation of neuron projection development
GO_0098868Biological processbone growth
GO_0021670Biological processlateral ventricle development
GO_0043010Biological processcamera-type eye development
GO_0033344Biological processcholesterol efflux
GO_0021540Biological processcorpus callosum morphogenesis
GO_0042632Biological processcholesterol homeostasis
GO_0005615Cellular componentextracellular space
GO_0050431Molecular functiontransforming growth factor beta binding

IV. Literature review

[source]
Gene nameTSKU
Protein nameTsukushi (E2-induced gene 4 protein) (Leucine-rich repeat-containing protein 54)
Tsukushi, small leucine rich proteoglycan
SynonymsE2IG4
UNQ850/PRO1788
LRRC54
TSK
DescriptionFUNCTION: Contributes to various developmental events and other processes such as wound healing and cholesterol homeostasis through its interactions with multiple signaling pathways. Wnt signaling inhibitor which competes with WNT2B for binding to Wnt receptor FZD4 and represses WNT2B-dependent development of the peripheral eye. Plays a role in regulating the hair cycle by controlling TGFB1 signaling. Required for the development of the anterior commissure in the brain by inhibiting neurite outgrowth. Essential for terminal differentiation of hippocampal neural stem cells. Plays a role in regulating bone elongation and bone mass by modulating growth plate chondrocyte function and overall body size. Required for development of the inner ear through its involvement in stereocilia formation in inner hair cells. Facilitates wound healing by inhibiting secretion of TGFB1 from macrophages which prevents myofibroblast differentiation, maintaining inflammatory cell quiescence. Plays a role in cholesterol homeostasis by reducing circulating high-density lipoprotein cholesterol, lowering cholesterol efflux capacity and decreasing cholesterol-to-bile acid conversion in the liver. In one study, shown to negatively regulate sympathetic innervation in brown fat, leading to reduced energy expenditure. In another study, shown not to affect brown fat thermogenic capacity, body weight gain or glucose homeostasis. .

AccessionsENST00000527881.1
Q8WUA8
E9PLG7
ENST00000533752.1
E9PN12
ENST00000333090.5
ENST00000525167.1
ENST00000612930.1