TSEN15 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006397Biological processmRNA processing
GO_0006388Biological processtRNA splicing, via endonucleolytic cleavage and ligation
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005515Molecular functionprotein binding
GO_0003676Molecular functionnucleic acid binding

IV. Literature review

[source]
Gene nameTSEN15
Protein nameChromosome 1 open reading frame 19, isoform CRA_a (tRNA splicing endonuclease subunit 15)
tRNA-splicing endonuclease subunit Sen15 (SEN15 homolog) (HsSEN15) (tRNA-intron endonuclease Sen15)
tRNA splicing endonuclease subunit 15
SynonymsSEN15
hCG_40901
C1orf19
DescriptionFUNCTION: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini . There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events . .

AccessionsENST00000533373.6
ENST00000647437.1
A0A2R8YHG0
A0A2R8Y5L0
ENST00000645668.2 [Q8WW01-1]
ENST00000643916.1
ENST00000644145.1
A0A2R8YEM0
A0A2R8YDU8
ENST00000646297.2
ENST00000643231.1
ENST00000423085.7 [Q8WW01-2]
H0YCV5
ENST00000644815.1
Q8WW01
ENST00000644592.1
ENST00000645963.2
E9PPN1
ENST00000485209.6
A0A2R8YG40
A0A2R8Y6B3
ENST00000643702.1
F2Z3M0
A0A2R8Y6M5
ENST00000644479.1
A0A2R8Y5W5
ENST00000361641.6
A0A2U3TZM3
A0A2R8Y5Q6
A0A2R8Y6A4
ENST00000647465.1
ENST00000462677.3