TRUB2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRUB2 at tissue level.

III. Associated gene sets

GO_1990481Biological processmRNA pseudouridine synthesis
GO_0070131Biological processpositive regulation of mitochondrial translation
GO_0006397Biological processmRNA processing
GO_0008033Biological processtRNA processing
GO_0035770Cellular componentribonucleoprotein granule
GO_0005739Cellular componentmitochondrion
GO_0005759Cellular componentmitochondrial matrix
GO_0009982Molecular functionpseudouridine synthase activity
GO_0160148Molecular functiontRNA pseudouridine(55) synthase activity
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameTRUB2
Protein namePseudouridylate synthase TRUB2, mitochondrial (EC 5.4.99.-) (TruB pseudouridine synthase homolog 2) (tRNA pseudouridine 55 synthase TRUB2) (Psi55 synthase TRUB2) (EC 5.4.99.25)
Synonyms
DescriptionFUNCTION: Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs . As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation . Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs . .

AccessionsENST00000372890.6 [O95900-1]
O95900