TRPM2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002407Biological processdendritic cell chemotaxis
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0051489Biological processregulation of filopodium assembly
GO_0009408Biological processresponse to heat
GO_0071502Biological processcellular response to temperature stimulus
GO_0071577Biological processzinc ion transmembrane transport
GO_0097553Biological processcalcium ion transmembrane import into cytosol
GO_0019722Biological processcalcium-mediated signaling
GO_0098703Biological processcalcium ion import across plasma membrane
GO_0014074Biological processresponse to purine-containing compound
GO_0033194Biological processresponse to hydroperoxide
GO_0051209Biological processrelease of sequestered calcium ion into cytosol
GO_0097028Biological processdendritic cell differentiation
GO_0071421Biological processmanganese ion transmembrane transport
GO_0071277Biological processcellular response to calcium ion
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0071415Biological processcellular response to purine-containing compound
GO_0001659Biological processtemperature homeostasis
GO_0006816Biological processcalcium ion transport
GO_0035725Biological processsodium ion transmembrane transport
GO_0070588Biological processcalcium ion transmembrane transport
GO_0051289Biological processprotein homotetramerization
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0043204Cellular componentperikaryon
GO_0005764Cellular componentlysosome
GO_0070821Cellular componenttertiary granule membrane
GO_0101003Cellular componentficolin-1-rich granule membrane
GO_0042995Cellular componentcell projection
GO_0005765Cellular componentlysosomal membrane
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0005272Molecular functionsodium channel activity
GO_0016787Molecular functionhydrolase activity
GO_0005261Molecular functionmonoatomic cation channel activity
GO_0099604Molecular functionligand-gated calcium channel activity
GO_0005384Molecular functionmanganese ion transmembrane transporter activity
GO_0072571Molecular functionmono-ADP-D-ribose binding
GO_0047631Molecular functionADP-ribose diphosphatase activity
GO_0015278Molecular functionintracellularly gated calcium channel activity
GO_0005509Molecular functioncalcium ion binding
GO_0005262Molecular functioncalcium channel activity

IV. Literature review

[source]
Gene nameTRPM2
Protein nameTRPM2 protein
Transient receptor potential cation channel subfamily M member 2 (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) (Transient receptor potential melastatin 2)
Truncated tumor-enriched TRPM2 (cDNA FLJ50244, highly similar to Transient receptor potential cation channel subfamily M member 2)
Transient receptor potential cation channel, subfamily M, member 2, striatum short form (SSF-TRPM2)
Transient receptor potential cation channel subfamily M member 2
SynonymsLTRPC2
EREG1
KNP3
TRPC7
DescriptionFUNCTION: [Isoform 1]: Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels . Functions as a ligand-gated ion channel . Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening . Extracellular calcium passes through the channel and increases channel activity . Contributes to Ca(2+) release from intracellular stores in response to ADP-ribose . Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (Probable). Besides, mediates the release of lysosomal Zn(2+) stores in response to reactive oxygen species, leading to increased cytosolic Zn(2+) levels . Activated by moderate heat (35 to 40 degrees Celsius) . Activated by intracellular ADP-ribose, beta-NAD (NAD(+)) and similar compounds, and by oxidative stress caused by reactive oxygen or nitrogen species . The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate . Activation by ADP-ribose and beta-NAD is strongly increased by moderate heat (35 to 40 degrees Celsius) . Likewise, reactive oxygen species lower the threshold for activation by moderate heat (37 degrees Celsius) . Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis. Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca(2+) levels (By similarity). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection. Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca(2+) levels (By similarity). Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its role in increasing cytoplasmic Ca(2+) and Zn(2+) levels . Confers susceptibility to cell death following oxidative stress . .; FUNCTION: [Isoform 2]: Lacks cation channel activity. Does not mediate cation transport in response to oxidative stress or ADP-ribose. .; FUNCTION: [Isoform 3]: Lacks cation channel activity and negatively regulates the channel activity of isoform 1. Negatively regulates susceptibility to cell death in reposponse to oxidative stress. .

AccessionsENST00000300482.9 [O94759-1]
Q14DR2
O94759
ENST00000397932.6
E9PGK7
ENST00000431901.5
ENST00000397928.6 [O94759-1]
B4DVI8
C9JZQ8
Q5KTC1
ENST00000300481.13 [O94759-2]