TRPA1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRPA1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRPA1 at tissue level.

III. Associated gene sets

GO_0019233Biological processsensory perception of pain
GO_0019722Biological processcalcium-mediated signaling
GO_0006811Biological processmonoatomic ion transport
GO_0050966Biological processdetection of mechanical stimulus involved in sensory perception of pain
GO_0014070Biological processresponse to organic cyclic compound
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0050968Biological processdetection of chemical stimulus involved in sensory perception of pain
GO_0048265Biological processresponse to pain
GO_0009409Biological processresponse to cold
GO_0050955Biological processthermoception
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0070588Biological processcalcium ion transmembrane transport
GO_0007166Biological processcell surface receptor signaling pathway
GO_0051289Biological processprotein homotetramerization
GO_0005886Cellular componentplasma membrane
GO_0032421Cellular componentstereocilium bundle
GO_0097604Molecular functiontemperature-gated cation channel activity
GO_0015267Molecular functionchannel activity
GO_0042802Molecular functionidentical protein binding
GO_0015278Molecular functionintracellularly gated calcium channel activity
GO_0005262Molecular functioncalcium channel activity

IV. Literature review

[source]
Gene nameTRPA1
Protein nameTransient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor)
Transient receptor potential cation channel subfamily A member 1
SynonymsANKTM1
DescriptionFUNCTION: Receptor-activated non-selective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function . Shows 8-fold preference for divalent over monovalent cations . Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of irritants, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an irritant from tears gas and vehicle exhaust fumes . Acts also as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana . Is activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds. Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner, whereas mechanisms of non-electrophilic ligands are not well determined. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity). .

AccessionsENST00000262209.5
O75762
ENST00000523582.5
H0YAW0