I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| dendritic cell | 3 studies | 20% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| dendritic cell | 3 studies | 20% ± 1% |
Insufficient scRNA-seq data for expression of TRMT2A at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 2120.86 | 226 / 226 | 100% | 26.31 | 406 / 406 |
| ovary | 100% | 2375.68 | 180 / 180 | 100% | 20.75 | 430 / 430 |
| pancreas | 100% | 1790.06 | 328 / 328 | 100% | 24.66 | 178 / 178 |
| thymus | 100% | 3007.86 | 653 / 653 | 100% | 32.48 | 605 / 605 |
| uterus | 100% | 2495.30 | 170 / 170 | 100% | 32.48 | 459 / 459 |
| skin | 100% | 2122.63 | 1809 / 1809 | 100% | 40.01 | 471 / 472 |
| brain | 100% | 1821.23 | 2635 / 2642 | 100% | 32.29 | 705 / 705 |
| prostate | 100% | 3143.87 | 245 / 245 | 100% | 34.88 | 500 / 502 |
| esophagus | 100% | 2017.65 | 1445 / 1445 | 99% | 14.51 | 182 / 183 |
| kidney | 100% | 2005.91 | 89 / 89 | 99% | 20.19 | 895 / 901 |
| adrenal gland | 100% | 3125.45 | 258 / 258 | 99% | 24.79 | 228 / 230 |
| intestine | 100% | 2203.19 | 966 / 966 | 99% | 22.55 | 522 / 527 |
| stomach | 100% | 1900.80 | 359 / 359 | 99% | 19.20 | 283 / 286 |
| lung | 100% | 1996.04 | 577 / 578 | 99% | 27.07 | 1144 / 1155 |
| bladder | 100% | 2254.10 | 21 / 21 | 99% | 32.40 | 498 / 504 |
| breast | 100% | 2511.93 | 459 / 459 | 99% | 23.42 | 1102 / 1118 |
| adipose | 100% | 2140.01 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 28.71 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 54.49 | 29 / 29 |
| spleen | 100% | 4166.24 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 28.03 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 28.68 | 1 / 1 |
| blood vessel | 100% | 1819.69 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 1292.39 | 796 / 803 | 0% | 0 | 0 / 0 |
| heart | 99% | 1102.92 | 850 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 96% | 1547.80 | 896 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006397 | Biological process | mRNA processing |
| GO_0032259 | Biological process | methylation |
| GO_0008033 | Biological process | tRNA processing |
| GO_0005829 | Cellular component | cytosol |
| GO_0008169 | Molecular function | C-methyltransferase activity |
| GO_0030697 | Molecular function | tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent |
| GO_0005515 | Molecular function | protein binding |
| GO_0003723 | Molecular function | RNA binding |
| Gene name | TRMT2A |
| Protein name | tRNA methyltransferase 2 homolog A tRNA (uracil-5-)-methyltransferase homolog A (EC 2.1.1.35) (mRNA (uracil-5-)-methyltransferase TRMT2A) (EC 2.1.1.-) tRNA (uracil(54)-C(5))-methyltransferase (EC 2.1.1.35) |
| Synonyms | |
| Description | FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and some mRNAs . Mainly catalyzes the methylation of uridine at position 54 (m5U54) in cytosolic tRNAs . Also able to mediate the formation of 5-methyl-uridine in some mRNAs . . |
| Accessions | ENST00000492988.5 ENST00000439169.2 ENST00000444256.1 C9K041 H7BZZ4 ENST00000445045.1 ENST00000403707.7 [Q8IZ69-1] F2Z2W7 Q8IZ69 A0A994J4Q5 ENST00000404751.7 [Q8IZ69-2] ENST00000252136.12 [Q8IZ69-1] ENST00000444845.5 H7C100 |
