TRIP13 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIP13 at tissue level.

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0007130Biological processsynaptonemal complex assembly
GO_0007283Biological processspermatogenesis
GO_0006302Biological processdouble-strand break repair
GO_0007131Biological processreciprocal meiotic recombination
GO_0007141Biological processmale meiosis I
GO_0001556Biological processoocyte maturation
GO_0051598Biological processmeiotic recombination checkpoint signaling
GO_0007144Biological processfemale meiosis I
GO_0007094Biological processmitotic spindle assembly checkpoint signaling
GO_0048477Biological processoogenesis
GO_0007286Biological processspermatid development
GO_0005694Cellular componentchromosome
GO_0001673Cellular componentmale germ cell nucleus
GO_0005634Cellular componentnucleus
GO_0042802Molecular functionidentical protein binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameTRIP13
Protein namePachytene checkpoint protein 2 homolog (Human papillomavirus type 16 E1 protein-binding protein) (16E1-BP) (HPV16 E1 protein-binding protein) (Thyroid hormone receptor interactor 13) (Thyroid receptor-interacting protein 13) (TR-interacting protein 13) (TRIP-13)
Pachytene checkpoint protein 2 homolog (TR-interacting protein 13) (TRIP-13) (Thyroid hormone receptor interactor 13) (Thyroid receptor-interacting protein 13)
SynonymsPCH2
DescriptionFUNCTION: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity). Plays a role in mitotic spindle assembly checkpoint (SAC) activation . .

FUNCTION: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. .

AccessionsENST00000513435.1
H0YAL2
ENST00000166345.8 [Q15645-1]
Q15645