TRIM34 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM34 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	633.27	576 / 578	3%	0.04	30 / 1155
breast	100%	567.57	457 / 459	1%	0.02	12 / 1118
bladder	100%	561.10	21 / 21	1%	0.01	3 / 504
uterus	100%	540.28	170 / 170	0%	0.01	2 / 459
intestine	100%	581.94	966 / 966	0%	0	0 / 527
ovary	100%	708.58	180 / 180	0%	0	0 / 430
prostate	100%	535.85	245 / 245	0%	0	0 / 502
spleen	100%	1424.32	241 / 241	0%	0	0 / 0
stomach	100%	385.22	359 / 359	0%	0	0 / 286
thymus	100%	560.96	653 / 653	0%	0	0 / 605
skin	100%	542.36	1806 / 1809	0%	0	0 / 472
adipose	100%	545.99	1202 / 1204	0%	0	0 / 0
adrenal gland	100%	968.63	257 / 258	0%	0	0 / 230
esophagus	100%	391.52	1439 / 1445	0%	0	0 / 183
kidney	99%	493.62	88 / 89	0%	0.01	1 / 901
blood vessel	99%	403.31	1317 / 1335	0%	0	0 / 0
peripheral blood	98%	1129.27	915 / 929	0%	0	0 / 0
pancreas	94%	200.63	307 / 328	0%	0	0 / 178
heart	88%	182.71	761 / 861	0%	0	0 / 0
liver	86%	176.56	195 / 226	0%	0	0 / 406
brain	41%	64.48	1088 / 2642	0%	0	0 / 705
muscle	16%	20.50	129 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0000209	Biological process	protein polyubiquitination
GO_0051091	Biological process	positive regulation of DNA-binding transcription factor activity
GO_0045087	Biological process	innate immune response
GO_0051607	Biological process	defense response to virus
GO_0032880	Biological process	regulation of protein localization
GO_0051092	Biological process	positive regulation of NF-kappaB transcription factor activity
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0010508	Biological process	positive regulation of autophagy
GO_0046596	Biological process	regulation of viral entry into host cell
GO_0005739	Cellular component	mitochondrion
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0042803	Molecular function	protein homodimerization activity
GO_0019901	Molecular function	protein kinase binding
GO_0042802	Molecular function	identical protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0003674	Molecular function	molecular_function

Gene name	TRIM34
Protein name	E3 ubiquitin-protein ligase TRIM34 (EC 2.3.2.27) (Interferon-responsive finger protein 1) (RING finger protein 21)
Synonyms	IFP1 RNF21
Description	FUNCTION: Functions as antiviral protein and contributes to the defense against retroviral infections . Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses . During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination . In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis . Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis . Promotes also the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells . .
Accessions	ENST00000429814.3 [Q9BYJ4-1] Q9BYJ4 ENST00000514226.5 [Q9BYJ4-1]

TRIM34 report