TRIM3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015031Biological processprotein transport
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0000209Biological processprotein polyubiquitination
GO_0007399Biological processnervous system development
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0017148Biological processnegative regulation of translation
GO_0034141Biological processpositive regulation of toll-like receptor 3 signaling pathway
GO_0030425Cellular componentdendrite
GO_0005794Cellular componentGolgi apparatus
GO_0005737Cellular componentcytoplasm
GO_0005769Cellular componentearly endosome
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0030371Molecular functiontranslation repressor activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameTRIM3
Protein nameTripartite motif containing 3
Alternative protein TRIM3
Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97)
SynonymsBERP
RNF22
RNF97
DescriptionFUNCTION: E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (By similarity). In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation. Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (By similarity). Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (By similarity). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity). Induces growth arrest via its RING-dependent E3 ligase activity and ubiquinates CDKN1A . Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3 . In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes . .

AccessionsENST00000536344.5 [O75382-4]
ENST00000525074.5 [O75382-1]
L8EAL7
ENST00000345851.8 [O75382-1]
E9PMK8
ENST00000528227.5
ENST00000529529.1
E9PMW5
O75382
ENST00000359518.7 [O75382-1]