TRIM10 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRIM10 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM10 at tissue level.

III. Associated gene sets

GO_0030218Biological processerythrocyte differentiation
GO_0016567Biological processprotein ubiquitination
GO_0046597Biological processnegative regulation of viral entry into host cell
GO_0008150Biological processbiological_process
GO_0045087Biological processinnate immune response
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameTRIM10
Protein nameTripartite motif-containing protein 10 (B30-RING finger protein) (RING finger protein 9)
SynonymsRNF9
RFB30
DescriptionFUNCTION: E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells. May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (By similarity). In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity. Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1 . .

AccessionsENST00000447465.2 [Q9UDY6-2]
ENST00000446013.2 [Q9UDY6-2]
ENST00000451727.2 [Q9UDY6-1]
ENST00000413055.2 [Q9UDY6-2]
ENST00000354038.10 [Q9UDY6-1]
ENST00000428611.6 [Q9UDY6-2]
ENST00000456988.6 [Q9UDY6-1]
Q9UDY6
ENST00000449208.6 [Q9UDY6-1]
ENST00000449742.7 [Q9UDY6-1]
ENST00000376704.3 [Q9UDY6-2]
ENST00000259941.6 [Q9UDY6-2]
ENST00000426996.6 [Q9UDY6-1]
ENST00000416714.2 [Q9UDY6-2]
ENST00000417411.6 [Q9UDY6-2]
ENST00000431258.6 [Q9UDY6-1]
ENST00000448645.2 [Q9UDY6-1]