TRBV2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRBV2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRBV2 at tissue level.

III. Associated gene sets

GO_0007166Biological processcell surface receptor signaling pathway
GO_0002250Biological processadaptive immune response
GO_0005886Cellular componentplasma membrane
GO_0042101Cellular componentT cell receptor complex

IV. Literature review

[source]
Gene nameTRBV2
Protein nameT cell receptor beta variable 2
mRNA
Synonyms
DescriptionFUNCTION: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity . .

AccessionsENST00000632828.1
ENST00000455382.2
A0A8S4QAS5
A0A1B0GX68
A0A0J9YWF9